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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Spence C D, Mathai M, Mills E H, Coghlan J P, Whitworth J A, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1989 Jul;16(7):607-19. doi: 10.1111/j.1440-1681.1989.tb01611.x.

Adrenocorticotrophin (ACTH) administration to sheep produces a rapid adrenally dependent hypertension which is maximal after 3 days and associated with increased cardiac output (CO) and heart rate (HR), while calculated total peripheral resistance remains unchanged. 2. This study investigated the proposal that a centrally mediated increase in sympathetic activity is important in the development of ACTH-induced hypertension. 3. Concomitant intravenous infusions of either clonidine (60 micrograms/kg per day) or methyldopa (60 mg/kg per day) with ACTH (5 micrograms/kg per day) failed to inhibit the increase in mean arterial pressure (MAP) observed with ACTH. 4. In a separate experiment clonidine abolished the increase in CO and HR but not the pressor response associated with ACTH administration. 5. These results do not support a role for centrally mediated increase in sympathetic activity in the genesis of ACTH-induced hypertension.

给绵羊注射促肾上腺皮质激素（ACTH）会迅速引发依赖肾上腺的高血压，3天后达到最大值，同时伴有心输出量（CO）增加和心率（HR）加快，而计算得出的总外周阻力保持不变。2. 本研究调查了以下观点：中枢介导的交感神经活动增加在ACTH诱导的高血压发展中起重要作用。3. 可乐定（每天60微克/千克）或甲基多巴（每天60毫克/千克）与ACTH（每天5微克/千克）同时静脉输注，未能抑制观察到的ACTH引起的平均动脉压（MAP）升高。4. 在另一项实验中，可乐定消除了CO和HR的升高，但没有消除与ACTH给药相关的升压反应。5. 这些结果不支持中枢介导的交感神经活动增加在ACTH诱导的高血压发生中起作用。

Spence C D, Mathai M, Mills E H, Coghlan J P, Whitworth J A, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1989 Jul;16(7):607-19. doi: 10.1111/j.1440-1681.1989.tb01611.x.

Adrenocorticotrophin (ACTH) administration to sheep produces a rapid adrenally dependent hypertension which is maximal after 3 days and associated with increased cardiac output (CO) and heart rate (HR), while calculated total peripheral resistance remains unchanged. 2. This study investigated the proposal that a centrally mediated increase in sympathetic activity is important in the development of ACTH-induced hypertension. 3. Concomitant intravenous infusions of either clonidine (60 micrograms/kg per day) or methyldopa (60 mg/kg per day) with ACTH (5 micrograms/kg per day) failed to inhibit the increase in mean arterial pressure (MAP) observed with ACTH. 4. In a separate experiment clonidine abolished the increase in CO and HR but not the pressor response associated with ACTH administration. 5. These results do not support a role for centrally mediated increase in sympathetic activity in the genesis of ACTH-induced hypertension.

给绵羊注射促肾上腺皮质激素（ACTH）会迅速引发依赖肾上腺的高血压，3天后达到最大值，同时伴有心输出量（CO）增加和心率（HR）加快，而计算得出的总外周阻力保持不变。2. 本研究调查了以下观点：中枢介导的交感神经活动增加在ACTH诱导的高血压发展中起重要作用。3. 可乐定（每天60微克/千克）或甲基多巴（每天60毫克/千克）与ACTH（每天5微克/千克）同时静脉输注，未能抑制观察到的ACTH引起的平均动脉压（MAP）升高。4. 在另一项实验中，可乐定消除了CO和HR的升高，但没有消除与ACTH给药相关的升压反应。5. 这些结果不支持中枢介导的交感神经活动增加在ACTH诱导的高血压发生中起作用。