Mason R T, Coghlan J P, Denton D A, Graham W F, Humphery T J, Scoggins B A, Whitworth J A
J Cardiovasc Pharmacol. 1984 Mar-Apr;6(2):288-92. doi: 10.1097/00005344-198403000-00013.
The short- and long-term effects of indomethacin administration were examined in normotensive and ACTH-induced hypertensive conscious sheep. Indomethacin, 1 mg/kg/h for 60 min, caused a transient rise in mean arterial pressure (MAP) and calculated total peripheral resistance (CTPR) and a fall in cardiac output in normotensive sheep. In sheep with ACTH hypertension, these haemodynamic effects were prolonged. Indomethacin infusion at 3 mg/kg/day for 3 days had no observable haemodynamic or metabolic effects. Concomitant infusion of ACTH increased MAP and CTPR. These studies suggest prostaglandins play only a minor role in regulation of blood pressure in normal conscious sheep, but modulate the blood pressure rise in ACTH hypertension in sheep.
在正常血压和促肾上腺皮质激素（ACTH）诱导的高血压清醒绵羊中研究了吲哚美辛给药的短期和长期影响。在正常血压绵羊中，以1mg/kg/h的剂量输注吲哚美辛60分钟，导致平均动脉压（MAP）短暂升高、计算得出的总外周阻力（CTPR）升高以及心输出量下降。在患有ACTH高血压的绵羊中，这些血流动力学效应持续时间延长。以3mg/kg/天的剂量输注吲哚美辛3天没有观察到血流动力学或代谢效应。同时输注ACTH会使MAP和CTPR升高。这些研究表明，前列腺素在正常清醒绵羊的血压调节中仅起次要作用，但可调节绵羊ACTH高血压中的血压升高。
