Choi H S, Hong J W, Lee J H, Noh J H, Kim D J
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Koyang, Gyeonggi-do, South Korea.
Intern Med J. 2015 Apr;45(4):428-35. doi: 10.1111/imj.12672.
Albuminuria is associated with increased risk of multiple adverse health outcomes, such as progressive renal failure, cardiovascular disease and death. However, in the general population, it is uncertain whether albuminuria is associated with elevated heart rate, which is an independent and powerful risk factor for cardiovascular disease.
To investigate whether an elevated heart rate is an independent factor associated with albuminuria in the general adult population of Korea.
A cross-sectional analysis was carried out on 5198 Korean adults aged 19 years or older who participated in the fifth (2011) Korea National Health and Nutrition Examination Survey (KNHANES V-2).
The prevalence of albuminuria showed an increasing trend throughout the whole range of heart rate, even after adjusting for confounders (P = 0.002). The increment was most profound at the heart rate of 70-75 and >76 beats per minute (b.p.m.; P = 0.011). In multiple logistic regression analysis, age (P < 0.001), hypertension (P < 0.001), diabetes (P < 0.001), hypertriglyceridaemia (P = 0.025), estimated glomerular filtration rate (P = 0.028) and heart rate (P = 0.023) were independently associated with the presence of albuminuria in Korean adults. Compared with participants with heart rate ≤ 64 b.p.m., the odds ratio (95% CI) for albuminuria was 1.50 (1.15-1.96) for those with heart rate ≥ 76 b.p.m.
The prevalence of albuminuria is independently associated with heart rate in the general adult population of Korea.
蛋白尿与多种不良健康结局风险增加相关，如进行性肾衰竭、心血管疾病和死亡。然而，在一般人群中，蛋白尿是否与心率升高相关尚不确定，而心率是心血管疾病的一个独立且强有力的危险因素。
调查心率升高是否是韩国一般成年人群中与蛋白尿相关的独立因素。
对参加第五次（2011年）韩国国家健康与营养检查调查（KNHANES V-2）的5198名19岁及以上的韩国成年人进行横断面分析。
即使在调整混杂因素后，蛋白尿患病率在整个心率范围内仍呈上升趋势（P = 0.002）。在心率为70 - 75次/分钟和>76次/分钟时增加最为显著（P = 0.011）。在多因素逻辑回归分析中，年龄（P < 0.001）、高血压（P < 0.001）、糖尿病（P < 0.001）、高甘油三酯血症（P = 0.025）、估计肾小球滤过率（P = 0.028）和心率（P = 0.023）与韩国成年人蛋白尿的存在独立相关。与心率≤64次/分钟的参与者相比，心率≥76次/分钟的参与者蛋白尿的比值比（95%CI）为1.50（1.15 - 1.96）。
在韩国一般成年人群中，蛋白尿患病率与心率独立相关。
