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在韩国基因组与流行病学研究（KoGES）中，微量白蛋白尿作为8年期间新发糖尿病的一个简单预测指标。

Microalbuminuria as a simple predictor of incident diabetes over 8 years in the Korean Genome and Epidemiology Study (KoGES).

作者信息

Jung Dong-Hyuk, Byun Young-Sup, Kwon Yu-Jin, Kim Gwang-Sil

机构信息

Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea.

Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital Inje University College of Medicine, Seoul, Republic of Korea.

出版信息

Sci Rep. 2017 Nov 13;7(1):15445. doi: 10.1038/s41598-017-15827-2.

DOI:10.1038/s41598-017-15827-2
PMID:29133894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5684338/
Abstract

Microalbuminuria (MAU) is a common subclinical disease and related with cardiovascular outcome both in diabetic and non-diabetic patients. However, there is rare data about the effect of MAU on the development of diabetes. Thus, we aimed to investigate whether MAU is associated with the development of incident diabetes. A total of 3385 subjects without diabetes (1503 men and 1882 women; mean age, 53 years) who participated in the Ansung-Ansan cohort study from 2001-2002 (baseline) to 2011-2012 (fifth follow-up visit) were followed for a mean of 8 years. The prevalence of MAU at baseline was 10.8% (365 patients), and the incidence of newly developed diabetes during the follow-up period was 15.3% (56 patients) in subjects with MAU. The hazard ratio (HR) for development of diabetes was 1.43 (95% confidence interval (CI) 1.07-1.91, p-value 0.016), independent of traditional risk factors for diabetes including pre-diabetes, age, obesity, and family history. The impact of MAU on diabetes was also significant in the non-pre-diabetic population (HR 2.08, 95% CI 1.07-4.03, p-value 0.031). In conclusion, our results show that incident MAU is associated with future development of diabetes and could be an early marker for diabetes, even in the non-prediabetic population.

摘要

微量白蛋白尿（MAU）是一种常见的亚临床疾病，在糖尿病患者和非糖尿病患者中均与心血管结局相关。然而，关于MAU对糖尿病发生发展影响的数据很少。因此，我们旨在研究MAU是否与新发糖尿病的发生有关。共有3385名无糖尿病的受试者（1503名男性和1882名女性；平均年龄53岁）参与了2001年至2002年（基线）至2011年至2012年（第五次随访）的安城-安山队列研究，平均随访8年。基线时MAU的患病率为10.8%（365例患者），MAU患者在随访期间新发糖尿病的发生率为15.3%（56例患者）。糖尿病发生的风险比（HR）为1.43（95%置信区间（CI）1.07-1.91，p值0.016），独立于糖尿病的传统危险因素，包括糖尿病前期、年龄、肥胖和家族史。MAU对非糖尿病前期人群糖尿病的影响也很显著（HR 2.08，95%CI 1.07-4.03，p值0.031）。总之，我们的结果表明，新发MAU与糖尿病的未来发展相关，即使在非糖尿病前期人群中也可能是糖尿病的早期标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e0/5684338/720c96ec4527/41598_2017_15827_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e0/5684338/8a07465ec4d7/41598_2017_15827_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e0/5684338/329ad7223161/41598_2017_15827_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e0/5684338/720c96ec4527/41598_2017_15827_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e0/5684338/8a07465ec4d7/41598_2017_15827_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e0/5684338/329ad7223161/41598_2017_15827_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e0/5684338/720c96ec4527/41598_2017_15827_Fig3_HTML.jpg

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Evaluation of Urinary Indices for Albuminuria and Proteinuria in Patients with Chronic Kidney Disease.慢性肾脏病患者白蛋白尿和蛋白尿的尿液指标评估
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