Rabey Karyne N, Li Yao, Norton John N, Reynolds Randall P, Schmitt Daniel
Department of Evolutionary Anthropology, Duke University, Durham, NC, USA,
Ann Biomed Eng. 2015 Aug;43(8):1957-64. doi: 10.1007/s10439-014-1226-y. Epub 2014 Dec 23.
Vibrations in research facilities can cause complex animal behavioral and physiological responses that can affect animal health and research outcomes. The goal of this study was to determine the range of frequency values, where animals are unable to attenuate vibrations, and therefore may be most susceptible to their effects. Anesthetized and euthanized adult rats and mice were exposed to vibration frequencies over a wide range (0-600 Hz) and at a constant magnitude of 0.3 m/s(2). Euthanized animals were additionally exposed to vibrations at an acceleration of 1 m/s(2). The data showed that at most frequencies rodents were able to attenuate vibration magnitudes, with values for the back-mounted accelerometer being substantially less than that of the table. At frequencies of 41-60 Hz mice did not attenuate vibration magnitude, but instead the magnitude of the table and animal were equal or amplified. Rats experienced the same pattern of non-attenuation between 31 and 50 Hz. Once euthanized, the mice vibrated at a slightly more elevated frequency (up to 100 Hz). Based on these results, it may be prudent that in laboratory settings, vibrations in the ranges reported here should be accounted for as possible contributors to animal stress and/or biomechanical changes.
研究设施中的振动会引发复杂的动物行为和生理反应，进而影响动物健康及研究结果。本研究的目的是确定动物无法减弱振动的频率值范围，因此它们可能最易受到振动影响。将麻醉和安乐死的成年大鼠和小鼠暴露于广泛的频率范围（0 - 600赫兹），振动幅度恒定为0.3米/秒²。对安乐死的动物还额外施加了1米/秒²加速度的振动。数据显示，在大多数频率下，啮齿动物能够减弱振动幅度，背部安装的加速度计测量值明显低于台面测量值。在41 - 60赫兹频率下，小鼠无法减弱振动幅度，相反，台面和动物的振动幅度相等或增大。大鼠在31 - 50赫兹之间出现相同的非减弱模式。安乐死后，小鼠振动频率略有升高（高达100赫兹）。基于这些结果，在实验室环境中，或许应谨慎考虑此处报告的频率范围内的振动，因为它们可能是导致动物应激和/或生物力学变化的因素。
