Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA.
J Occup Environ Med. 2010 Jun;52(6):584-94. doi: 10.1097/JOM.0b013e3181e12b1f.
The current frequency weighting proposed in the International Standards Organization-5349 standard may underestimate the risk of injury associated with exposure to vibration >100 Hz. The goal of this study was to assess the frequency-dependent responses of the peripheral vascular system to repeated bouts of vibration.
The effects of exposure to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49 m/s2) on vascular morphology, oxidative stress, inflammation, and gene expression were examined in the ventral tail artery of rats.
Vascular responses indicative of dysfunction (eg, remodeling and oxidative activity) became more pronounced as the frequency of the exposure increased.
Exposure to vibration frequencies that induce the greatest stress and strain on the tail (ie, >100 Hz) result in vascular changes indicative of dysfunction.
国际标准化组织 5349 标准中提出的当前频率加权可能低估了与暴露于 >100 Hz 振动相关的损伤风险。本研究的目的是评估外周血管系统对重复振动冲击的频率依赖性反应。
在大鼠腹尾动脉中，检查了暴露于 62.5、125 或 250 Hz（49 m/s2 的恒定加速度）振动对血管形态、氧化应激、炎症和基因表达的影响。
血管功能障碍的反应（例如，重塑和氧化活性）随着暴露频率的增加而变得更加明显。
暴露于对尾巴产生最大应力和应变的振动频率（即>100 Hz）会导致血管功能障碍的变化。
