Buhr J, Berghäuser K H, Morr H, Dobroschke J
Zentrum für Pathologie, Universität Giessen.
Dtsch Med Wochenschr. 1989 Oct 20;114(42):1597-601. doi: 10.1055/s-2008-1066801.
Pleural lavage with 300 ml physiological saline was undertaken at thoracotomy (before and after resection) in a prospective study of 59 patients (49 males and 10 females; average age 59.7 years, range 41-76 years) with first manifestations of a bronchial carcinoma. The aim was to find out whether, even at an early stage of the tumour, there are tumour deposits in the pleural cavity. The lavage fluid was centrifuged and the sediment then embedded in paraffin and prepared for cytological examination. Tumour cells were demonstrated before resection in 27 patients (45.8%), in 23 of them also after the resection. Among 38 patients, previously classified as being in stage I, the lavage material was positive in 15 (39.5%); tumour cells were demonstrated in 5 of 18 patients in stage pT1. The cumulative two-year survival rate of non-small-cell bronchial carcinoma in stage I (n = 32) was 39.9% if the lavage was positive, 97.4% if negative (P less than 0.01). The results indicate that a positive finding on pleural lavage corresponds to a pT4 stage with a poor life expectancy.
在一项对59例（49例男性和10例女性；平均年龄59.7岁，范围41 - 76岁）首次表现为支气管癌的患者进行的前瞻性研究中，在开胸手术时（切除前后）用300毫升生理盐水进行胸腔灌洗。目的是查明即使在肿瘤早期，胸腔内是否存在肿瘤沉积物。将灌洗液体离心，然后将沉淀物包埋在石蜡中并准备进行细胞学检查。27例患者（45.8%）在切除前发现肿瘤细胞，其中23例在切除后也发现肿瘤细胞。在38例先前分类为I期的患者中，灌洗材料阳性的有15例（39.5%）；在pT1期的18例患者中有5例发现肿瘤细胞。I期（n = 32）非小细胞支气管癌患者，如果灌洗阳性，两年累积生存率为39.9%，如果灌洗阴性则为97.4%（P小于0.01）。结果表明，胸腔灌洗阳性结果对应于pT4期，预期寿命较差。
