Buhr J, Berghäuser K H, Gonner S, Schäffer R, Padberg W M
Klinik für Allgemein, Justus-Liebig-Universität Giessen.
Zentralbl Chir. 1996;121(2):90-5.
319 patients with the first manifestation of lung cancer underwent intraoperative pleural lavage (lavage I = after opening the chest; lavage II = after resection of lung cancer). Tumor cells were found in lavage I in 122 patients (38.2%), in 94 of them also in lavage II. In only 9 cases we found tumor cells in lavage II cytologically. The cumulative five-year survival rate of non-small cell lung cancer in stage I (n = 154) was 22.1% if lavage was positive (lavage I and II, n = 44), and 64.3% if lavage was negative (n = 110) (p < 0.05). Additionally, we performed tissue cultures of tumor-free parenchyma in 23 cases of lung cancer. In 16 cases (69.6%) we detected tumor cells by histology and immunhistology. Intraoperative pleural lavage should be done when assessing the final tumor stage. A positive result should be added to the pTNM-classification of lung cancer.
319例首次表现为肺癌的患者接受了术中胸膜灌洗（灌洗I = 开胸后；灌洗II = 肺癌切除后）。122例患者（38.2%）在灌洗I中发现肿瘤细胞，其中94例在灌洗II中也发现肿瘤细胞。仅9例在灌洗II细胞学检查中发现肿瘤细胞。I期非小细胞肺癌（n = 154）患者中，灌洗阳性（灌洗I和II，n = 44）时5年累积生存率为22.1%，灌洗阴性（n = 110）时为64.3%（p < 0.05）。此外，我们对23例肺癌患者的无瘤实质进行了组织培养。16例（69.6%）通过组织学和免疫组织学检测到肿瘤细胞。评估最终肿瘤分期时应进行术中胸膜灌洗。阳性结果应添加到肺癌的pTNM分类中。
