Cheung Karmen, Das Diganta B
a Department of Chemical Engineering , Loughborough University , Loughborough , Leicestershire , UK.
Drug Deliv. 2016 Sep;23(7):2338-2354. doi: 10.3109/10717544.2014.986309. Epub 2014 Dec 23.
In recent years, there has been a surge in the research and development of microneedles (MNs), a transdermal delivery system that combines the technology of transdermal patches and hypodermic needles. The needles are in the hundreds of micron length range and therefore allow relatively little or no pain. For example, biodegradable MNs have been researched in the literature and have several advantages compared with solid or hollow MNs, as they produce non-sharp waste and can be designed to allow rapid or slow release of drugs. However, they also pose a disadvantage as successful insertion into the stratum corneum layer of the skin relies on sufficient mechanical strength of the biodegradable material. This review looks at the various technologies developed in MN research and shows the rapidly growing numbers of research papers and patent publications since the first invention of MNs (using time series statistical analysis). This provides the research and industry communities a valuable synopsis of the trends and progress being made in this field.
近年来，微针（MNs）的研发激增，微针是一种将透皮贴片技术和皮下注射针技术相结合的经皮给药系统。这些针的长度在数百微米范围内，因此引起的疼痛相对较小或几乎没有疼痛。例如，可生物降解微针已在文献中得到研究，与实心或空心微针相比有几个优点，因为它们产生无尖锐的废物，并且可以设计成允许药物快速或缓慢释放。然而，它们也有一个缺点，即成功插入皮肤角质层依赖于可生物降解材料足够的机械强度。本综述着眼于微针研究中开发的各种技术，并（使用时间序列统计分析）显示自微针首次发明以来研究论文和专利出版物数量的快速增长。这为研究界和工业界提供了该领域趋势和进展的宝贵概述。
