Khoddam Rubin, Worley Matthew, Browne Kendall C, Doran Neal, Brown Sandra A
Veterans Medical Research Foundation, San Diego, CA, United States.
San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, United States.
Drug Alcohol Depend. 2015 Feb 1;147:235-42. doi: 10.1016/j.drugalcdep.2014.11.009. Epub 2014 Nov 26.
This study explored whether the density of family history (FH) of substance use disorders relates to post-treatment substance use outcomes in adolescents, with the primary aim of determining whether FH exerts a relatively stronger influence on longer-term outcomes.
The present investigation examined adolescents (ages 12-18, n=366) from two independent samples who were treated for alcohol/substance use disorder (ASUD) and re-assessed during the eight years following treatment with identical methodology. Primary substance use outcomes were assessed at 1, 2, 4, 6, and 8 years post-treatment and included total drinks, days using marijuana, and days using other drugs.
In hierarchical linear models there were significant FH density×linear time interactions for total drinks (z=12.75, p<0.001) and marijuana use days (z=4.39, p<0.001); greater FH density predicted more total drinks and more marijuana use days, with both associations becoming stronger over time. The increasing linkage between FH and other drug use was not significant over time.
Findings are consistent with previous research indicating that the risk associated with FH increases over time, especially in relation to quantity/frequency measures of alcohol and marijuana use. By extending these findings to an adolescent clinical sample, the current study highlights that FH density of alcohol and drug dependence is a risk factor for poorer long-term outcomes for adolescent-onset ASUD youth as they transition into adulthood. Future work should explore the mechanisms underlying greater post-treatment substance use for adolescents/young adults with greater FH density.
本研究探讨物质使用障碍家族史（FH）的密度是否与青少年治疗后的物质使用结果相关，主要目的是确定FH是否对长期结果产生相对更强的影响。
本调查研究了来自两个独立样本的青少年（年龄12 - 18岁，n = 366），他们因酒精/物质使用障碍（ASUD）接受治疗，并在治疗后的八年中采用相同方法进行重新评估。主要物质使用结果在治疗后1年、2年、4年、6年和8年进行评估，包括饮酒总量、使用大麻的天数和使用其他药物的天数。
在分层线性模型中，饮酒总量（z = 12.75，p < 0.001）和使用大麻天数（z = 4.39，p < 0.001）存在显著的FH密度×线性时间交互作用；更高的FH密度预示着更多的饮酒总量和更多的使用大麻天数，且这两种关联随着时间推移变得更强。FH与其他药物使用之间的关联随时间增加不显著。
研究结果与先前的研究一致，表明与FH相关的风险随时间增加，特别是与酒精和大麻使用的数量/频率指标相关。通过将这些发现扩展到青少年临床样本，本研究强调酒精和药物依赖的FH密度是青少年起病的ASUD青年向成年期过渡时长期结果较差的一个风险因素。未来的工作应探索FH密度较高的青少年/年轻人治疗后物质使用增加的潜在机制。
