Papadimitriou Konstantinos, Karkavelas George, Vouros Ioannis, Kessopoulou Eftichia, Konstantinidis Antonis
Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School Aristotle University, Thessaloniki, Greece.
Medical School, Aristotle University, Thessaloniki, Greece.
J Craniomaxillofac Surg. 2015 Mar;43(2):232-7. doi: 10.1016/j.jcms.2014.11.011. Epub 2014 Nov 20.
Simvastatin (SIM), which is widely used in hyperlipidemia treatment, has also attracted attention due to its anabolic effects on bones. This study is designed to investigate the effectiveness of 2 mg SIM combined with 3 different carriers as delivery systems. Bone defects were surgically created in the femoral bones of 14 New Zealand white rabbits. The carriers used were the inorganic bovine bone graft (BOS), the hydroxyapatite combined with calcium sulfate (HACS), and the collagen sponge (COS). The bone defects were divided for each time period into 7 groups, as follows: passive control group (CONT), active control groups (BOS), (HACS) and (COS) (no simvastatin), and groups (BOS + SIM), (HACS + SIM) (carrier and simvastatin combination). Animal were sacrificed at 4 and 8 weeks postoperatively, and bone defects areas were prepared for histological examination and histomorphometric evaluation. Analysis of variance demonstrated statistically significant differences between groups depending on the carrier used. At 4 weeks, the BOS + SIM group presented higher rates of new bone formation, whereas at 8 weeks more new bone formation was noted for the HACS + SIM group. This study suggests that local application of simvastatin, combined with an appropriate carrier, can promote new bone formation.
辛伐他汀（SIM）被广泛用于治疗高脂血症，其对骨骼的合成代谢作用也引起了关注。本研究旨在调查2毫克辛伐他汀与3种不同载体作为递送系统联合使用的有效性。在14只新西兰白兔的股骨上手术制造骨缺损。使用的载体为无机牛骨移植物（BOS）、羟基磷灰石与硫酸钙的组合（HACS）以及胶原海绵（COS）。每个时间段的骨缺损分为7组，如下：被动对照组（CONT）、主动对照组（BOS）、（HACS）和（COS）（无辛伐他汀），以及（BOS + SIM）组、（HACS + SIM）组（载体与辛伐他汀组合）。术后4周和8周处死动物，制备骨缺损区域用于组织学检查和组织形态计量学评估。方差分析表明，根据所使用的载体不同，各实验组之间存在统计学显著差异。在4周时，BOS + SIM组呈现出更高的新骨形成率，而在8周时，HACS + SIM组观察到更多的新骨形成。本研究表明，辛伐他汀与合适的载体联合局部应用可促进新骨形成。
