局部应用辛伐他汀对兔骨膜牵张成骨的影响。

Effects of local simvastatin on periosteal distraction osteogenesis in rabbits.

作者信息

Kahraman O E, Erdogan Ö, Namli H, Sencar L

机构信息

Private Practice, Adana, Turkey.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cukurova University, Adana, Turkey; Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Rangsit University, Pathum Thani, Thailand.

出版信息

Br J Oral Maxillofac Surg. 2015 Apr;53(4):e18-22. doi: 10.1016/j.bjoms.2015.01.006. Epub 2015 Jan 29.

DOI:10.1016/j.bjoms.2015.01.006

PMID:25640700

Abstract

Our aim was to evaluate the effect of local simvastatin on the formation of new bone using a new design of periosteal distractor. The distractors were placed between the periosteum and bone at the inferior border of the mandible of 20 New Zealand rabbits. In the first group (n=10) simvastatin was applied locally to the distraction zone. The other 10 rabbits served as controls. The formation of new bone was evaluated with digital direct radiography, computed tomography (CT), and histomorphometric analyses. New bone formed in all rabbits, but more formed in the experimental group according to histomorphometric variables. However, other measurements did not differ significantly between the groups. The new design of the periosteal distraction device was successful in causing new bone to form. Local simvastatin made no significant contribution to the procedure.

摘要

我们的目的是使用一种新型骨膜牵张器设计来评估局部辛伐他汀对新骨形成的影响。将牵张器置于20只新西兰兔下颌骨下缘的骨膜与骨之间。第一组（n = 10）在牵张区域局部应用辛伐他汀。另外10只兔子作为对照。通过数字直接放射摄影、计算机断层扫描（CT）和组织形态计量学分析来评估新骨的形成。所有兔子均形成了新骨，但根据组织形态计量学变量，实验组形成的新骨更多。然而，两组之间的其他测量结果没有显著差异。骨膜牵张装置的新设计成功地促使了新骨形成。局部应用辛伐他汀对该过程没有显著贡献。