Cohen J S, Levy H P, Sloan J, Dariotis J, Biesecker B B
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA.
McKusick Nathans Institute of Genetic Medicine and Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Clin Genet. 2015 Nov;88(5):425-30. doi: 10.1111/cge.12551. Epub 2015 Jan 20.
Neurofibromatosis type 1 (NF1) carries a significant psychosocial burden for affected individuals. The objective of this study was to measure the prevalence of depressive symptoms among a large sample of adults with NF1 and to quantify the impact of depressive symptoms on quality of life (QoL). This cross-sectional study used an Internet-based questionnaire to collect data from 498 adults who self-reported as having NF1. Using the Center for Epidemiologic Studies Depression (CESD) scale, 55% of all participants (61% of females and 43% of males) scored above 16, indicating a high likelihood of clinical depression. In a multivariate regression model controlling for demographics and potential confounders, depressive symptoms accounted for 32% of the variance in QoL as measured by the Quality of Life Index. This study is the largest to date and found the highest prevalence of depression compared to prior studies. Our data provide more compelling evidence that individuals with NF1 are at increased risk for psychiatric morbidity and suggest that this population should be routinely screened for depression. Because depression was found to be strongly associated with QoL and accounted for nearly one-third of the variance in QoL, it is likely that effectively treating depression may significantly enhance QoL for individuals with NF1.
1型神经纤维瘤病（NF1）给患者带来了巨大的心理社会负担。本研究的目的是测量一大群成年NF1患者中抑郁症状的患病率，并量化抑郁症状对生活质量（QoL）的影响。这项横断面研究使用基于互联网的问卷，从498名自我报告患有NF1的成年人中收集数据。使用流行病学研究中心抑郁量表（CESD），所有参与者中有55%（女性为61%，男性为43%）得分高于16，表明临床抑郁症的可能性很高。在控制人口统计学和潜在混杂因素的多变量回归模型中，抑郁症状占生活质量指数所衡量的生活质量差异的32%。这项研究是迄今为止规模最大的，与之前的研究相比，发现抑郁症的患病率最高。我们的数据提供了更有说服力的证据，表明NF1患者患精神疾病的风险增加，并表明该人群应常规筛查抑郁症。由于发现抑郁症与生活质量密切相关，且占生活质量差异的近三分之一，有效治疗抑郁症可能会显著提高NF1患者的生活质量。
