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[支气管热成形术治疗重度成人哮喘]

[Bronchial thermoplasty in the treatment of severe adult asthma].

作者信息

Chanez P, Boulet L-P, Brillet P-Y, Joos G, Laviolette M, Louis R, Rochat T, Soccal P, Aubier M

机构信息

Inserm U1067 CNRS UMR 7333, service de pneumologie, AP-HM, Aix Marseille université, chemin des Bourrely, 13015 Marseille, France.

Centre de recherche, institut de cardiologie et de pneumologie de l'université Laval Québec, Québec, Canada.

出版信息

Rev Mal Respir. 2015 Feb;32(2):97-109. doi: 10.1016/j.rmr.2014.09.009. Epub 2014 Dec 19.

Abstract

Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based treatment, the evaluation procedure of risks and benefits is different that for pharmaceutical products; safety aspects, regulatory requirements, study design and the assessment of the magnitude of effects may all be different. The mechanism of action and optimal patient selection need to be assessed further in rigorous clinical and scientific studies. This technique is in harmony with the development of personalised medicine in the 21st century. It should be developed further in response to the numerous challenges and needs not yet met in the management of severe asthma.

摘要

支气管热成形术是一种用于治疗重度哮喘的最新内镜技术。它是一种创新疗法,其临床疗效和安全性正开始得到更好的认识。由于这是一种基于设备的治疗方法,其风险和益处的评估程序与药品不同;安全方面、监管要求、研究设计以及效果大小的评估可能都有所不同。作用机制和最佳患者选择需要在严格的临床和科学研究中进一步评估。这项技术与21世纪个性化医疗的发展相契合。针对重度哮喘管理中众多尚未满足的挑战和需求,应进一步发展该技术。

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