海葵二素-2，一种来自海洋双鞭毛虫海葵属的具有强大细胞毒性活性的新型线性聚酮化合物。

Amphirionin-2, a novel linear polyketide with potent cytotoxic activity from a marine dinoflagellate Amphidinium species.

作者信息

Kumagai Keiko, Minamida Mika, Akakabe Mai, Tsuda Masayuki, Konishi Yuko, Tominaga Akira, Tsuda Masashi, Fukushi Eri, Kawabata Jun

机构信息

Science Research Center, Kochi University, Kochi 783-8505, Japan.

Department of Applied Science, Kochi University, Kochi 783-8502, Japan.

出版信息

Bioorg Med Chem Lett. 2015 Feb 1;25(3):635-8. doi: 10.1016/j.bmcl.2014.12.003. Epub 2014 Dec 8.

DOI:10.1016/j.bmcl.2014.12.003

PMID:25534608

Abstract

A novel linear polyketide, amphirionin-2 (1), with two unique hexahydrofuro[3,2-b]furan moieties has been isolated from the cultivated algal cells of a benthic dinoflagellate Amphidinium sp. (strain KCA09051). The structure was elucidated on the basis of detailed analyses of 2D NMR data, and the absolute configuration of C-5 was determined by using modified Mosher's method. Amphirionin-2 (1) exhibited potent cytotoxic activity against human colon carcinoma Caco-2 cells and human lung adenocarcinoma A549 cells.

摘要

从底栖双鞭毛藻Amphidinium sp.（菌株KCA09051）的培养藻细胞中分离出一种新型线性聚酮化合物——海葵素-2（1），其具有两个独特的六氢呋喃并[3,2 - b]呋喃部分。基于二维核磁共振数据的详细分析阐明了其结构，并使用改良的莫舍尔方法确定了C-5的绝对构型。海葵素-2（1）对人结肠癌Caco-2细胞和人肺腺癌A549细胞表现出强大的细胞毒性活性。