Microbiology Laboratory, Department of Life Sciences, Dibrugarh University, Dibrugarh, Assam, 786004, India.
Department of Pharmaceutical Sciences, Faculty of Science and Engineering, Dibrugarh University, Dibrugarh, Assam, 786004, India.
Arch Microbiol. 2024 Feb 26;206(3):122. doi: 10.1007/s00203-024-03829-4.
Endophytes are considered one of the major sources of bioactive compounds used in different aspects of health care including cancer treatment. When colonized, they either synthesize these bioactive compounds as a part of their secondary metabolite production or augment the host plant machinery in synthesising such bioactive compounds. Hence, the study of endophytes has drawn the attention of the scientific community in the last few decades. Among the endophytes, endophytic fungi constitute a major portion of endophytic microbiota. This review deals with a plethora of anti-cancer compounds derived from endophytic fungi, highlighting alkaloids, lignans, terpenes, polyketides, polyphenols, quinones, xanthenes, tetralones, peptides, and spirobisnaphthalenes. Further, this review emphasizes modern methodologies, particularly omics-based techniques, asymmetric dihydroxylation, and biotic elicitors, showcasing the dynamic and evolving landscape of research in this field and describing the potential of endophytic fungi as a source of anticancer drugs in the future.
内生菌被认为是生物活性化合物的主要来源之一，这些化合物被用于医疗保健的多个方面，包括癌症治疗。当它们被定殖时，它们要么将这些生物活性化合物合成为其次生代谢产物的一部分，要么增强宿主植物合成这些生物活性化合物的机制。因此，内生菌的研究在过去几十年中引起了科学界的关注。在内生菌中，内生真菌构成了内生微生物群的主要部分。本综述涉及了大量源自内生真菌的抗癌化合物，重点介绍了生物碱、木脂素、萜类、聚酮类、多酚类、醌类、黄烷酮类、四氢萘酮类、肽类和螺双萘并呋喃类化合物。此外，本综述强调了现代方法，特别是基于组学的技术、不对称二羟基化和生物诱导剂，展示了该领域研究的动态和不断发展的格局，并描述了内生真菌作为未来抗癌药物来源的潜力。
