Zubov A N, Grishchenko I I, Nosyreva E D
Farmakol Toksikol. 1989 Jul-Aug;52(4):17-20.
Effects of two central antimuscarinic drugs, namely N-methyl-4-piperidinol benzylate and tropine phenylcyclopentylglycolate on Na currents in internally dialyzed mouse neuroblastoma cells were studied using the suction-pipette voltage-clamp technique. Like amine local anesthetics, the both compounds produce two phenomenologically different types of sodium current inhibition: a steady block without conditioning and a cumulative (use-dependent) block which develops during repetitive membrane pulsing. The ability of these m-cholinoblockers to modulate voltage-dependent ionic permeability of the neuronal membranes is supposed to be one of possible components in the mechanism of their both main and accessory (non-synaptic) effects.
采用吸液管电压钳技术研究了两种中枢抗毒蕈碱药物，即N-甲基-4-哌啶醇苄酯和托品苯环戊基乙醇酸酯对经内部透析的小鼠神经母细胞瘤细胞钠电流的影响。与胺类局部麻醉药一样，这两种化合物产生两种现象学上不同类型的钠电流抑制：无预处理的稳定阻断和在重复膜脉冲期间发展的累积（使用依赖性）阻断。这些M胆碱阻断剂调节神经元膜电压依赖性离子通透性的能力被认为是其主要和辅助（非突触）作用机制中可能的组成部分之一。
