Lee Seung Ku, Kim Jin-Seok, Kim Seong Hwan, Kim Yong Hyun, Lim Hong Euy, Kim Eung Ju, Park Chang Gyu, Cho Goo-Yeong, Kim Jinyoung, Baik Inkyung, Park Juri, Lee Jung Bok, Shin Chol
Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea;
Division of Cardiology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea;
Am J Hypertens. 2015 Aug;28(8):1010-6. doi: 10.1093/ajh/hpu254. Epub 2014 Dec 22.
The effect of sodium intake on the cardiovascular system remains controversial. The purpose of this study is to investigate the relation between sodium intake and cardiovascular structure and function in the nonhypertensive population.
We performed a cross-sectional analysis in 1,586 nonhypertensive subjects who participated in the Korean Genome Epidemiology Study (2007-2008). Sodium intake was assessed by estimating the 24-hour urinary sodium excretion from a spot urine sample. Changes in cardiovascular structure and function were assessed by using tissue Doppler echocardiography, the carotid intima-media thickness (CIMT), and the brachial-ankle pulse wave velocity (baPWV).
Systolic and diastolic blood pressures increased with increasing tertiles of estimated 24-hour urinary sodium excretion. In multivariate analyses adjusting for covariates, there were stepwise decreases in the baPWV (P = 0.003) and CIMT (P = 0.001) values as the estimated 24-hour urinary sodium excretion increased, whereas no significant differences in left ventricular (LV) structural and functional parameters were observed across the tertiles of estimated 24-hour urinary sodium excretion. Multiple linear regression analyses revealed that the estimated 24-hour urinary sodium excretion was independently and inversely associated with baPWV (P < 0.001) and CIMT (P = 0.001), but not with LV parameters.
In the nonhypertensive population, urinary sodium excretion was inversely related to baPWV and CIMT. However, there were no associations between urinary sodium excretion and LV structure or function.
钠摄入对心血管系统的影响仍存在争议。本研究的目的是调查非高血压人群中钠摄入与心血管结构和功能之间的关系。
我们对1586名参与韩国基因组流行病学研究（2007 - 2008年）的非高血压受试者进行了横断面分析。通过从随机尿样估计24小时尿钠排泄量来评估钠摄入。使用组织多普勒超声心动图、颈动脉内膜中层厚度（CIMT）和臂踝脉搏波速度（baPWV）评估心血管结构和功能的变化。
随着估计的24小时尿钠排泄量三分位数的增加，收缩压和舒张压升高。在对协变量进行调整的多变量分析中，随着估计的24小时尿钠排泄量增加，baPWV值（P = 0.003）和CIMT值（P = 0.001）呈逐步下降，而在估计的24小时尿钠排泄量三分位数之间，左心室（LV）结构和功能参数未观察到显著差异。多元线性回归分析显示，估计的24小时尿钠排泄量与baPWV（P < 0.001）和CIMT（P = 0.001）独立且呈负相关，但与LV参数无关。
在非高血压人群中，尿钠排泄与baPWV和CIMT呈负相关。然而，尿钠排泄与LV结构或功能之间无关联。
