CD28基因多态性（rs3116496）与癌症的关联：一项荟萃分析。
The association of CD28 polymorphism, rs3116496, with Cancer: A meta-analysis.
作者信息
Baek Jihae, Lee Heeyoung, Hwang Kwang Woo, Kim Eunyoung, Min Hyeyoung
机构信息
College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
出版信息
Comput Biol Med. 2015 Jun;61:172-7. doi: 10.1016/j.compbiomed.2014.11.019. Epub 2014 Dec 9.
OBJECTIVE
To determine the relationship between CD28 polymorphisms, rs3116496, and cancer.
DESIGN
Meta-analysis.
METHODS
PubMed, EMBASE, Web of Science, and Cochrane library databases were searched to identify studies reporting the association between CD28 polymorphism and cancer. Two authors selected identified studies, extracted, and analyzed the data independently.
RESULTS
Individuals carrying a T allele (TT homozygotes and TT+TC heterozygotes) at rs3116496 had a lower incidence of cancer than carriers of a C allele. Subgroup analysis showed that this association held true for Asians, but not Europeans.
CONCLUSION
CD28 polymorphism, rs3116496, contributes to cancer susceptibility in the case of multiple cancers.
目的
确定CD28基因多态性rs3116496与癌症之间的关系。
设计
荟萃分析。
方法
检索PubMed、EMBASE、科学网和考克兰图书馆数据库，以识别报告CD28基因多态性与癌症关联的研究。两位作者独立选择已识别的研究、提取并分析数据。
结果
rs3116496位点携带T等位基因（TT纯合子和TT+TC杂合子）的个体患癌几率低于携带C等位基因的个体。亚组分析表明，这种关联在亚洲人中成立，但在欧洲人中不成立。
结论
CD28基因多态性rs3116496在多种癌症中与癌症易感性有关。
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