钾离子通道基因 KCNK2 在重度抑郁症中的作用。
The role of the potassium channel gene KCNK2 in major depressive disorder.
机构信息
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
出版信息
Psychiatry Res. 2015 Feb 28;225(3):489-92. doi: 10.1016/j.psychres.2014.11.061. Epub 2014 Dec 9.
Six single nucleotide polymorphisms (SNPs) of the KCNK2 gene were investigated for their association with major depressive disorder (MDD) and treatment efficacy in 590 MDD patients and 441 controls. The A homozygotes of rs10779646 were significantly more frequent in patients than controls whereas G allele of rs7549184 was associated with the presence of psychotic symptoms and the severity of disease. Evaluating the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we confirmed our findings.
研究了 KCNK2 基因的 6 个单核苷酸多态性（SNPs）与 590 例 MDD 患者和 441 例对照者的主要抑郁症（MDD）和治疗效果的相关性。rs10779646 的 A 纯合子在患者中明显比对照者更常见，而 rs7549184 的 G 等位基因与精神病症状的存在和疾病的严重程度有关。评估了缓解抑郁的序贯治疗选择（STAR*D）数据集，我们证实了我们的发现。
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