Shao Huawei, Hang Hu, Yunyun Jin, Hongfei Jiang, Chunmao Han, Zhang Jufang, Shen Haiyan, Zhu Fei, Jia Ming, Wang Yuyan, Guo Xiaobo
Department of Burns and Wound Center, Second Affiliated Hospital, College of Medicine, Zhejiang University;
Department of Plastic Surgery, Hangzhou First People's Hospital, Hangzhou, People's Republic of China.
Plast Surg (Oakv). 2014 Winter;22(4):249-53. doi: 10.4172/plastic-surgery.1000885.
Cicatricial alopecia encompasses a diverse group of disorders characterized by the permanent destruction of hair follicles and irreversible hair loss. Follicular unit transplantation was developed in 1994. However, large-scale clinical trials are necessary to study follicular unit transplantation for treating Chinese cicatricial alopecia patients.
To investigate the efficacy of follicular unit transplantation in the treatment of cicatricial alopecia in Chinese patients.
Patients with cicatricial alopecia were enrolled. The designated recipient area, follicular unit density of the donor site, transplanted density and operative time were recorded. Postoperative follow-up was conducted within six to 24 months; the density of hair in the recipient area was calculated using a Folliscope (Hansderma Co, USA). Patients' self-reported satisfaction and long-term complications were recorded.
Thirty-seven patients were enrolled. Cicatricial alopecia was caused by burns (n=8), trauma (n=21) and plastic surgery (cleft lip and palate repair [n=8]). Burn patients had a significantly larger bald area than the other patients (P<0.01). The operative time was significantly correlated with recipient area. The longest operation was 14.5 h; the largest transplanted area was 96 cm(2). At follow-up, the surviving follicular unit density/transplanted follicular unit density rate was 64.29% to 95.00% (mean 78.96%); the surviving/transplanted (S/T) area was 100% for 30 patients, 90% to 100% for five patients and <90% for two patients. The lowest S/T area was 82.81%. The S/T index was significantly and inversely correlated with operative time. Regarding long-term complications, two patients had postoperative epidermoid cysts that healed with local treatment.
Follicular unit transplantation is an effective method for treating cicatricial alopecia. It is relatively safe and yields satisfactory postoperative results. Extending the results of the present study to Chinese clinical practice is warranted.
瘢痕性秃发包括多种疾病，其特征为毛囊永久性破坏和不可逆性脱发。毛囊单位移植于1994年得以发展。然而，有必要开展大规模临床试验来研究毛囊单位移植治疗中国瘢痕性秃发患者的效果。
探讨毛囊单位移植治疗中国瘢痕性秃发患者的疗效。
纳入瘢痕性秃发患者。记录指定受区、供区毛囊单位密度、移植密度及手术时间。术后6至24个月进行随访；使用毛发密度计（美国Hansderma公司）计算受区毛发密度。记录患者自我报告的满意度及远期并发症。
共纳入37例患者。瘢痕性秃发由烧伤（n = 8）、创伤（n = 21）及整形手术（唇腭裂修复术[n = 8]）所致。烧伤患者的秃发面积显著大于其他患者（P < 0.01）。手术时间与受区面积显著相关。最长手术时间为14.5小时；最大移植面积为96平方厘米。随访时，存活毛囊单位密度/移植毛囊单位密度率为64.29%至95.00%（平均78.96%）；30例患者的存活/移植（S/T）面积为100%，5例患者为90%至100%，2例患者<90%。最低S/T面积为82.81%。S/T指数与手术时间呈显著负相关。关于远期并发症，2例患者术后出现表皮样囊肿，经局部治疗后愈合。
毛囊单位移植是治疗瘢痕性秃发的有效方法。该方法相对安全，术后效果满意。有必要将本研究结果推广至中国临床实践。
