Ma Yafeng, Faller William J, Sansom Owen J, Brown Ewan R, Doig Tamasin N, Melton David W, Machesky Laura M
aBeatson Institute for Cancer Research, Glasgow bEdinburgh Cancer Centre cDepartment of Pathology, NHS Lothian, Western General Hospital dEdinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK eMedical Oncology Group, Ingham Institute for Applied Medical Research, School of Medicine, University of New South Wales, New South Wales, Australia.
Melanoma Res. 2015 Apr;25(2):169-72. doi: 10.1097/CMR.0000000000000135.
Levels of the actin bundling protein fascin correlate with invasion and metastasis and reveal prognostic value in many epithelial carcinomas. However, we know very little about the potential role of fascin in melanoma. The purpose of this study is to compare fascin expression in primary melanomas and melanoma metastasis. Fascin expression was examined through the immunohistochemistry of paraffin embedded tissue microarrays including 560 cores of primary tumour and metastasis. Fascin expression was significantly elevated in 48 metastases compared with 254 primary tumours (P=0.034). In 187 patients with primary melanomas, fascin was not correlated with survival (P=0.067), whereas low fascin was significantly correlated with the presence of ulceration (P=0.005). Our results indicate that fascin status does not correlate with progression in melanoma. Upregulated fascin expression was detected in melanoma metastases, but was not correlated to patient outcome.
肌动蛋白成束蛋白fascin的水平与侵袭和转移相关，并在许多上皮癌中显示出预后价值。然而，我们对fascin在黑色素瘤中的潜在作用知之甚少。本研究的目的是比较原发性黑色素瘤和黑色素瘤转移灶中fascin的表达情况。通过对包含560个原发性肿瘤和转移灶核心的石蜡包埋组织微阵列进行免疫组织化学检测fascin的表达。与254个原发性肿瘤相比，48个转移灶中fascin的表达显著升高（P=0.034）。在187例原发性黑色素瘤患者中，fascin与生存率无关（P=0.067），而低水平的fascin与溃疡的存在显著相关（P=0.005）。我们的结果表明，fascin状态与黑色素瘤的进展无关。在黑色素瘤转移灶中检测到fascin表达上调，但与患者预后无关。
