Department of Cellular and Molecular Physiology, the Pennsylvania State University College of Medicine, Hershey, PA, USA.
Department of Surgery, the Pennsylvania State University College of Medicine, Hershey, PA, USA.
FEBS J. 2021 Mar;288(5):1434-1446. doi: 10.1111/febs.15484. Epub 2020 Jul 23.
Fascin is an F-actin-bundling protein that cross-links individual actin filaments into straight and stiff bundles. Fascin overexpression in cancer is strongly associated with poor prognosis and metastatic progression across different cancer types. It is well established that fascin plays a causative role in promoting metastatic progression. We will review the recent progress in our understanding of mechanisms underlying fascin-mediated cancer metastasis. This review will cover the biochemical basis for fascin-bundling activity, the mechanisms by which cancer cells upregulate fascin expression and the mechanism underlying fascin-mediated cancer cell migration, invasion, and metastatic colonization. We propose that fascin has broad roles in both metastatic dissemination and metastatic colonization. Understanding these mechanisms will be crucial to the development of anti-metastasis therapeutics targeting fascin.
Fascin 是一种 F-actin 成束蛋白，它将单个肌动蛋白丝交联成直而硬的束。在不同类型的癌症中，Fascin 的过度表达与预后不良和转移进展密切相关。已经证实 fascin 在促进转移进展中起因果作用。我们将回顾我们对 fascin 介导的癌症转移机制的理解的最新进展。这篇综述将涵盖 fascin 成束活性的生化基础、癌细胞上调 fascin 表达的机制以及 fascin 介导的癌细胞迁移、侵袭和转移定植的机制。我们提出 fascin 在转移扩散和转移定植中都有广泛的作用。了解这些机制对于开发针对 fascin 的抗转移治疗至关重要。
