Arnott M A, Hay J
Department of Microbiology, The University, Leicester, UK.
J Antimicrob Chemother. 1989 Sep;24(3):339-45. doi: 10.1093/jac/24.3.339.
Therapeutic concentrations (0.3-1.5 mg/l) of pentamidine isethionate and pentamidine mesylate, obtained after parenteral administration of either drug, did not affect oxygen consumption in the stimulated neutrophilic granulocyte. At concentrations of 0.7, 1.1 and 1.5 mg/l, superoxide production, hydrogen peroxide production, myeloperoxidase (MPO)-mediated iodination and hexose monophosphate shunt activity were suppressed relative to untreated cells (P less than 0.001 in each case). The depression in each activity was dose-related. There was no significant difference between the drugs with regard to these impairments in neutrophilic granulocyte function. This lowered respiratory burst activity, which would lead to a depression of MPO-dependent and MPO-independent processes in stimulated neutrophilic granulocytes, may be due to drug induced dysfunction of NADPH-oxidase.
经肠胃外给予任何一种药物后获得的治疗浓度（0.3 - 1.5毫克/升）的乙磺酸盐喷他脒和甲磺酸盐喷他脒，均不影响受刺激的嗜中性粒细胞的耗氧量。在浓度为0.7、1.1和1.5毫克/升时，相对于未处理的细胞，超氧化物生成、过氧化氢生成、髓过氧化物酶（MPO）介导的碘化作用和磷酸己糖旁路活性均受到抑制（每种情况P均小于0.001）。每种活性的降低均与剂量相关。在嗜中性粒细胞功能的这些损害方面，两种药物之间无显著差异。这种降低的呼吸爆发活性，会导致受刺激的嗜中性粒细胞中MPO依赖性和MPO非依赖性过程的抑制，可能是由于药物诱导的NADPH氧化酶功能障碍所致。
