Arnott M A, Bennett N D, Cairns D, Hay J
Department of Medical Microbiology, University of Edinburgh Medical School, UK.
J Pharm Pharmacol. 1994 May;46(5):394-6. doi: 10.1111/j.2042-7158.1994.tb03824.x.
Therapeutic concentrations (0.3-1.5 mgL-1) of pentamidine isethionate, normally obtainable in-vivo after parenteral administration of the drug, did not affect the in-vitro activity of the enzymes lysozyme, beta-glucuronidase or myeloperoxidase released from zymosan-activated human neutrophilic granulocytes. At concentrations of 0.7, 1.1 and 1.5 mgL-1, activity of cytosolic enzymes lactate dehydrogenase and glucose-6-phosphate dehydrogenase were reduced relative to untreated cells (P < 0.001 and P < 0.01, respectively), but not in a dose-dependent fashion. Cell viability, as determined by dye-exclusion remained unaffected.
喷他脒异硫氰酸盐的治疗浓度（0.3 - 1.5 mgL-1），通常在肠胃外给药后可在体内获得，不影响从酵母聚糖激活的人嗜中性粒细胞释放的溶菌酶、β-葡萄糖醛酸酶或髓过氧化物酶的体外活性。在浓度为0.7、1.1和1.5 mgL-1时，与未处理的细胞相比，胞质酶乳酸脱氢酶和葡萄糖-6-磷酸脱氢酶的活性降低（分别为P < 0.001和P < 0.01），但并非呈剂量依赖性。通过染料排除法测定的细胞活力未受影响。
