Arnott M A, Hay J
Department of Microbiology, University Leicester, UK.
J Antimicrob Chemother. 1990 Feb;25(2):247-53. doi: 10.1093/jac/25.2.247.
Both pentamidine isethionate and pentamidine mesylate induced a depression in activity of the NADPH-dependent oxidase system of stimulated human neutrophilic granulocytes. This drug-induced effect occurred at concentrations of 0.7, 1.1 and 1.5 mg/l, values within the therapeutic range after parenteral administration of a standard dose of either pentamidine salt, and was dose-related. There was no significant difference between the two salts with regard to this suppression in neutrophilic granulocyte function. The reduced activity of the NADPH-dependent oxidase system, after incubation with pentamidine salts, may be associated with the previously observed depression in candidacidal capacity of human neutrophilic granulocytes treated with these drugs.
乙磺酸盐喷他脒和甲磺酸盐喷他脒均可导致受刺激的人嗜中性粒细胞中依赖烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的氧化酶系统活性降低。这种药物诱导效应发生在浓度为0.7、1.1和1.5mg/L时，这是在肠胃外给予标准剂量的任一喷他脒盐后治疗范围内的值，并且与剂量相关。在嗜中性粒细胞功能的这种抑制方面，两种盐之间没有显著差异。在用喷他脒盐孵育后，依赖NADPH的氧化酶系统活性降低，可能与之前观察到的用这些药物治疗的人嗜中性粒细胞的杀念珠菌能力降低有关。
