Nagy J T, Szabó T, Komáromi I, Sztojka I, Fóris G, Leövey A
Horm Metab Res. 1986 Jun;18(6):415-7. doi: 10.1055/s-2007-1012330.
Thyroxine (T4) pretreatment of A 23187-stimulated human granulocytes in 10(-5)-10(-6) M concentration range inhibited the superoxide anion production of these cells. T4 increased the level of oxidized form of glutathione, whereas the intracellular level of the reduced form decreased. A similar alteration in the ratio of the oxidized to reduced forms of glutathione was detected in granulocytes during yeast cell phagocytosis. In addition, conversion of T4 to triiodothyronine (T3) was also inhibited during phagocytosis. A possible competition between 5'-monodeiodination of T4 and the oxidative burst of human granulocytes is discussed.
在10⁻⁵ - 10⁻⁶ M浓度范围内，用甲状腺素（T4）预处理A23187刺激的人粒细胞，可抑制这些细胞超氧阴离子的产生。T4增加了谷胱甘肽氧化形式的水平，而还原形式的细胞内水平降低。在酵母细胞吞噬过程中，粒细胞中谷胱甘肽氧化形式与还原形式的比例也出现了类似变化。此外，吞噬过程中T4向三碘甲状腺原氨酸（T3）的转化也受到抑制。本文讨论了T4的5'-单脱碘作用与人类粒细胞氧化爆发之间可能存在的竞争关系。
