Phasukkijwatana Nopasak, Thaweerattanasilp Wilaipun, Laotaweerungsawat Sawarin, Rodanant Nuttawut, Singalavanija Apichart, Tanterdtham Jutalai, Namatra Chakrapong, Trinavarat Adisak, Thoongsuwan Somanus, Rattanawarinchai Kritpol, Thongyou Ketwarin
J Med Assoc Thai. 2014 Sep;97(9):947-53.
To examine subfoveal choroidal thickness (SFCT) in Thai population using enhanced depth imaging spectral- domain optical coherence tomography (EDI-OCT) and to study its correlation with foveal retinal pigment epithelium thickness (FRPE), central neurosensory retinal thickness (CNRT), age, and refraction.
Four hundred eighty eyes from 240 subjects without glaucoma, retinal, or choroidal diseases underwent scanning of the retina and choroid using EDI-OCT SFCT FRPE, and CNRT measurements were based on the 1:1 micron images and wereperformed by two independent observers. The reliability ofmeasurements between the observers was evaluated by intraclass correlation coefficient (ICC). The correlations of SFCT with FRPE, CNRT, age, and refractive error were analyzed
The mean age of the subjects was 36.22 years (range 20-81years). The means (95% reference intervals) of SFCT, CNRT andFRPE were 294.02 μm (137.14-450.90 μm), 174.22 μm (141.82-206.62 μm), and 41.94 μm (34.65-49.23 μm), respectively. SFCT and CNRThad excellent reliability between the two observers [ICC = 0.947 (95% CI, 0.918-0.963) and 0.929 (95% CI, 0.906-0.945), respectively], while FRPE showed good reliability [ICC = 0. 729 (95% CI, 0.637-0.793)]. SFCT had a low positive correlation with FRPE (r = 0.179, p<0. 0001) but not with CNRT (p = 0.317). SFCT showed a positive correlation with refraction (r = 0.338, p<0.0001) and a negative correlation with age (r = -0.166, p<0.0001). Regression analysis suggested that the SFCT decreased by 12.23 pm per one decade oflife and by 11.42 pm per one diopter of myopia.
Normal values of SFCT in Thai population were obtained SFCT significantly decreased with older age and higher myopia. SFCT was associated with FRPE, reflecting the same vascular supply of the choroid and retinal pigment epithelium. When measured with our technique based on the 1:1 micron images, the reliability ofSFCT measurement was very high despite highly morphologic inter-individual variations.
使用增强深度成像光谱域光学相干断层扫描（EDI-OCT）检查泰国人群的黄斑下脉络膜厚度（SFCT），并研究其与黄斑视网膜色素上皮厚度（FRPE）、中央神经感觉层视网膜厚度（CNRT）、年龄和屈光不正的相关性。
对240例无青光眼、视网膜或脉络膜疾病的受试者的480只眼睛进行视网膜和脉络膜扫描，使用EDI-OCT。SFCT、FRPE和CNRT测量基于1:1微米图像，由两名独立观察者进行。通过组内相关系数（ICC）评估观察者之间测量的可靠性。分析SFCT与FRPE、CNRT、年龄和屈光不正的相关性。
受试者的平均年龄为36.22岁（范围20-81岁）。SFCT、CNRT和FRPE的平均值（95%参考区间）分别为294.02μm（137.14-450.90μm）、174.22μm（141.82-206.62μm）和41.94μm（34.65-49.23μm）。两名观察者之间SFCT和CNRT具有出色的可靠性[ICC分别为0.947（95%CI，0.918-0.963）和0.929（95%CI，0.906-0.945）]，而FRPE显示出良好的可靠性[ICC=0.729（95%CI，0.637-0.793）]。SFCT与FRPE呈低度正相关（r=0.179，p<0.0001），但与CNRT无相关性（p=0.317）。SFCT与屈光不正呈正相关（r=0.338，p<0.0001），与年龄呈负相关（r=-0.166，p<0.0001）。回归分析表明，每增长十岁，SFCT降低12.23μm，每增加一屈光度近视，SFCT降低11.42μm。
获得了泰国人群SFCT的正常值。SFCT随年龄增长和近视度数增加而显著降低。SFCT与FRPE相关，反映了脉络膜和视网膜色素上皮相同的血管供应。当使用我们基于1:1微米图像的技术进行测量时，尽管个体间形态差异很大，但SFCT测量的可靠性非常高。
