Stanca Horia T, Petrović Zarko, Munteanu Mihnea
Vojnosanit Pregl. 2014 Nov;71(11):1072-7. doi: 10.2298/vsp130511056s.
Central retinal artery occlusion (CRAO) and branch retinal artery occlusion (BRAO) result in partial or complete retinal ischemia and sudden loss of vision; at this moment, there is no effective therapy for CRAO and BRAO. Transluminal Nd:YAG laser embolysis (TYE) represents a therapeutic approach used for retinal vascular occlusive diseases. The main indication is branch retinal artery occlusion with visible embolus; for central retinal artery occlusion this tehnique is hardly applicable. The principle of this method consists of intravascular embolus breakage using the 1064 nm Nd:YAG laser, focused on the embolus surface.
We presented 5 cases with BRAO, 3 with infero-temporal and 2 with supero-temporal BRAO, all of them treated with TYE, with variable results. All the patients had a visible embolus within the BRA, the laser applications being delivered directly to the embolus.
Despite our short-term experience regarding this therapeutical approach, we can resume that the moment of emboli distruction, as close as possible to the onset of the occlusion, is decisive for regaining vision and that applying the procedure correctly is superior to observation in most cases. Worldwide experience with TYE is still limited, but the technique seems feasible also when treating CRAO caused by visible emboli on the optic disc surface. This most certainly calls for random trials for identifying precisely the role of TYE in treatment of retinal occlusion pathology, though the relatively small number of properly diagnosed cases affects this objective. In all cases, the risks of TYE must be weighed against the possibility of severe and permanent loss of vision secondary to retinal artery occlusions.
视网膜中央动脉阻塞(CRAO)和视网膜分支动脉阻塞(BRAO)会导致部分或完全性视网膜缺血以及视力突然丧失;目前,对于CRAO和BRAO尚无有效的治疗方法。经腔Nd:YAG激光栓子溶解术(TYE)是一种用于视网膜血管阻塞性疾病的治疗方法。其主要适应证为可见栓子的视网膜分支动脉阻塞;对于视网膜中央动脉阻塞,该技术几乎不适用。此方法的原理是使用聚焦于栓子表面的1064 nm Nd:YAG激光使血管内栓子破碎。
我们报告了5例BRAO患者,其中3例为颞下分支动脉阻塞,2例为颞上分支动脉阻塞,均接受了TYE治疗,结果各异。所有患者在分支视网膜动脉内均可见栓子,激光直接作用于栓子。
尽管我们对此治疗方法的短期经验有限,但我们可以总结出,尽可能在阻塞发生后尽早进行栓子破坏对于恢复视力至关重要,并且在大多数情况下正确应用该手术优于观察。全球范围内关于TYE的经验仍然有限,但该技术在治疗由视盘表面可见栓子引起的CRAO时似乎也是可行的。尽管确诊病例数量相对较少影响了这一目标,但这无疑需要进行随机试验以精确确定TYE在视网膜阻塞性病变治疗中的作用。在所有情况下,都必须权衡TYE的风险与视网膜动脉阻塞继发严重且永久性视力丧失的可能性。