一种基于偶氮染料-罗丹明的荧光和比色探针，用于在乙醇水溶液中特异性检测Pd(2+)：合成、XRD表征、计算研究及活细胞成像
An azodye-rhodamine-based fluorescent and colorimetric probe specific for the detection of Pd(2+) in aqueous ethanolic solution: synthesis, XRD characterization, computational studies and imaging in live cells.
作者信息
Mahapatra Ajit Kumar, Manna Saikat Kumar, Maiti Kalipada, Mondal Sanchita, Maji Rajkishor, Mandal Debasish, Mandal Sukhendu, Uddin Md Raihan, Goswami Shyamaprosad, Quah Ching Kheng, Fun Hoong-Kun
机构信息
Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, West Bengal, India.
出版信息
Analyst. 2015 Feb 21;140(4):1229-36. doi: 10.1039/c4an01575d.
Azodye-rhodamine hybrid colorimetric fluorescent probe (L) has been designed and synthesized. The structure of L has been established based on single crystal XRD. It has been shown to act as a selective turn-on fluorescent chemosensor for Pd(2+) with >40 fold enhancement by exhibiting red emission among the other 27 cations studied in aqueous ethanol. The coordination features of the species of recognition have been computationally evaluated by DFT methods and found to have a distorted tetrahedral Pd(2+) center in the binding core. The probe (L) has been shown to detect Pd up to 0.45 μM at pH 7.4. Furthermore, the probe can be used to image Pd(2+) in living cells.
已设计并合成了偶氮染料-罗丹明杂化比色荧光探针（L）。L的结构已通过单晶X射线衍射确定。在乙醇水溶液中研究的其他27种阳离子中，L通过发出红色荧光，表现为对Pd(2+)具有选择性开启荧光化学传感器，增强倍数>40倍。已通过密度泛函理论（DFT）方法对识别物种的配位特征进行了计算评估，发现其结合核心中存在扭曲的四面体Pd(2+)中心。该探针（L）在pH 7.4时可检测高达0.45 μM的Pd。此外，该探针可用于活细胞中Pd(2+)的成像。
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