由重症肌无力患者来源的爱泼斯坦-巴尔病毒刺激的B淋巴细胞在体外合成抗乙酰胆碱受体抗体。
In vitro synthesis of antibodies to acetylcholine receptor by Epstein-Barr virus-stimulated B-lymphocytes derived from patients with myasthenia gravis.
作者信息
Brenner T, Timore Y, Wirguin I, Abramsky O, Steinitz M
机构信息
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
出版信息
J Neuroimmunol. 1989 Oct;24(3):217-22. doi: 10.1016/0165-5728(89)90119-7.
Peripheral blood lymphocytes and B-cells were obtained from patients with myasthenia gravis and stimulated in vitro with either pokeweed mitogen or Epstein-Barr virus (EBV), respectively. EBV stimulation of B-cells caused a production of antibodies to acetylcholine receptor in 15 of the 25 myasthenia gravis patients: the EBV stimulation of B-cells was more effective in this regard than the pokeweed mitogen stimulation of peripheral blood lymphocytes. The in vitro synthesis of anti-acetylcholine receptor antibodies was found to be positively correlated with both the patients' sera antibody titers and with the disease severity.
从重症肌无力患者中获取外周血淋巴细胞和B细胞，分别用商陆有丝分裂原或爱泼斯坦-巴尔病毒（EBV）在体外进行刺激。EBV刺激B细胞后，25例重症肌无力患者中有15例产生了抗乙酰胆碱受体抗体：在这方面，EBV刺激B细胞比商陆有丝分裂原刺激外周血淋巴细胞更有效。发现抗乙酰胆碱受体抗体的体外合成与患者血清抗体滴度和疾病严重程度均呈正相关。
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