Murphy Dan, Oshin Femi
Royal Cornwall Hospital, Truro, Cornwall, UK.
Cornwall & Isles of Scilly Health Protection Team, Sedgemoor Centre, St Austell, Cornwall, UK.
Arch Dis Child. 2015 Apr;100(4):364-5. doi: 10.1136/archdischild-2014-306134. Epub 2014 Dec 22.
To determine the proportion of Salmonella cases in children aged <5 years that were reptile-associated salmonellosis (RAS) and to compare the severity of illness.
To analyse all cases of salmonellosis reported to public health authorities in children aged under 5 years in the South West of the UK from January 2010 to December 2013 for reptile exposure, age, serotype, hospitalisation and invasive disease.
48 of 175 (27%) Salmonella cases had exposure to reptiles. The median age of RAS cases was significantly lower than non-RAS cases (0.5 vs 1.0 year). RAS cases were 2.5 times more likely to be hospitalised (23/48) compared with non-RAS cases (25/127; p=0.0002). This trend continued in cases aged under 12 months, with significantly more RAS cases hospitalised (19/38) than non-RAS cases (8/42; p=0.003). Significantly more RAS cases had invasive disease (8/48: 5 bacteraemia, 2 meningitis, 1 colitis) than non-RAS cases (4/127: 3 bacteraemia, 1 meningitis).
Reptile exposure was found in over a quarter of all reported Salmonella cases in children under 5 years of age. RAS is associated with young age, hospitalisation and invasive disease.
确定5岁以下儿童中与爬行动物相关的沙门氏菌病（RAS）在沙门氏菌病例中所占的比例，并比较疾病的严重程度。
分析2010年1月至2013年12月期间向英国西南部公共卫生当局报告的5岁以下儿童沙门氏菌病的所有病例，了解其与爬行动物的接触情况、年龄、血清型、住院情况和侵袭性疾病。
175例沙门氏菌病例中有48例（27%）接触过爬行动物。RAS病例的中位年龄显著低于非RAS病例（0.5岁对1.0岁）。与非RAS病例（25/127；p=0.0002）相比，RAS病例住院的可能性高2.5倍（23/48）。在12个月以下的病例中，这一趋势依然存在，RAS病例住院的比例（19/38）显著高于非RAS病例（8/42；p=0.003）。RAS病例发生侵袭性疾病的比例（8/48：5例菌血症、2例脑膜炎、1例结肠炎）显著高于非RAS病例（4/127：3例菌血症、1例脑膜炎）。
在所有报告的5岁以下儿童沙门氏菌病例中，超过四分之一的病例接触过爬行动物。RAS与低龄、住院和侵袭性疾病有关。
