Balaji Govindan, Maharani B, Ravichandran Velappan, Parthasarathi Thiyagarajan
Department of Dermato-Venereology, Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu, India.
Department of Pharmacology, Annapoorana Medical College and Hospitals, Salem, Tamil Nadu, India.
Indian J Pharmacol. 2014 Nov-Dec;46(6):653-4. doi: 10.4103/0253-7613.144942.
Black hairy tongue (BHT) also called as lingua villosa nigra, is a self limiting benign condition characterized by hypertrophy and elongation of filiform papillae of tongue with brown or black discoloration. Smoking, poor oral hygiene, xerostomia, using peroxide containing mouth washes, substance abuse and drugs (steroids, methyldopa, olanzapine, etc) are the predisposing factors. However its occurrence in relation to linezolid ingestion among south Indians has not been reported in PubMed database. Here we report a case, where significant association of linezolid intake with BHT was found in a 10-year-old boy, who was treated with tablet linezolid for post surgical infection of left side radial neck fracture. This case is reported for the rarity of occurrence with linezolid therapy. According to Naranjo adverse drug reaction (ADR) causality scale, the association of BHT due to linezolid in our case was probable.
黑毛舌（BHT）也称为黑绒毛舌，是一种自限性良性病症，其特征为舌丝状乳头肥大和伸长，并伴有棕色或黑色变色。吸烟、口腔卫生差、口干症、使用含过氧化物的漱口水、药物滥用及药物（类固醇、甲基多巴、奥氮平等）是诱发因素。然而，在PubMed数据库中尚未有关于南印度人服用利奈唑胺后出现黑毛舌的报道。在此，我们报告一例病例，一名10岁男孩因左侧桡骨颈骨折术后感染接受利奈唑胺片治疗，发现其黑毛舌与利奈唑胺摄入存在显著关联。报道此病例是因其在利奈唑胺治疗中发生的罕见性。根据Naranjo药物不良反应（ADR）因果关系量表，我们病例中利奈唑胺导致黑毛舌的关联很可能成立。
