Manthena Sathish, Ramesh Amitha, Srikanth Adusumilli, Ramoji Rao M V, Preethi P Lakshmi, Samatha Y Pallavi
Department of Periodontics, Drs. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Chinnoutpalli, India.
Department of Periodontics, A. B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangaluru, Karnataka, India.
J Basic Clin Pharm. 2014 Dec;6(1):24-8. doi: 10.4103/0976-0105.145775.
Antimicrobial efficacy of subgingival chlorhexidine (CHX) application using two different vehicles of delivery.
The aim was to evaluate the efficacy of CHX varnish and gel as an adjunct to scaling and root planing (SRP) in reducing microbial count within moderate to deep periodontal pockets.
Experimental parallel mouth study.
A total of 30 subjects between the age groups 25 and 55 years having moderate to severe periodontitis, with pocket depth ≥ 5 mm were selected for the study. The selected patients were randomized into three groups of 10 each. Subjects in Group 1 received SRP followed by subgingival application of CHX varnish, subjects in Group 2 received SRP followed by subgingival application of CHX gel, subjects in Group 3 received SRP alone. Subgingival plaque samples were collected to estimate mean motile and nonmotile microbial counts using dark field microscopy at baseline, 1 week, 1 month, and 3 months.
After 3 months, there was statistically significant reduction in nonmotile microbial count in all the three groups. Motile microbial count was significantly reduced in all the three groups till 1 month from baseline. Only subjects in Group 1 who received subgingival CHXvarnish after SRP showed a significant reduction in motile microbial count till 3 months from baseline.
Subgingival application of highly concentrated CHX varnish following SRP is beneficial in reducing microbial count in moderate to deep periodontal pockets.
使用两种不同递送载体进行龈下洗必泰(CHX)应用的抗菌效果。
评估CHX清漆和凝胶作为龈下刮治和根面平整(SRP)辅助手段在减少中度至深度牙周袋内微生物数量方面的疗效。
实验性平行口腔研究。
选取30名年龄在25至55岁之间、患有中度至重度牙周炎且牙周袋深度≥5mm的受试者进行研究。将入选患者随机分为三组,每组10人。第1组受试者接受SRP,随后进行龈下应用CHX清漆;第2组受试者接受SRP,随后进行龈下应用CHX凝胶;第3组受试者仅接受SRP。在基线、1周、1个月和3个月时,使用暗视野显微镜收集龈下菌斑样本,以估计平均活动和非活动微生物数量。
3个月后,所有三组的非活动微生物数量均有统计学意义的显著减少。直至基线后1个月,所有三组的活动微生物数量均显著减少。只有第1组中在SRP后接受龈下CHX清漆的受试者,其活动微生物数量在基线后3个月仍有显著减少。
SRP后龈下应用高浓度CHX清漆有助于减少中度至深度牙周袋内的微生物数量。