Shapira J, Sgan-Cohen H D, Stabholz A, Sela M N, Schurr D, Goultschin J
Department of Pediatric Dentistry, Faculty of Dental Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Spec Care Dentist. 1994 Jul-Aug;14(4):158-63. doi: 10.1111/j.1754-4505.1994.tb01124.x.
Local applications of sustained-released varnishes of chlorhexidine and arginine were used in a controlled pilot study of 34 mentally retarded patients, ages 18-45, assigned to one of these groups: chlorhexidine (C), arginine (A), or placebo (P). A professional scaling followed by four weeks of professional brushing to reach a Plaque Index (PII) and Gingival Index (GI) of 1.0 at baseline preceded eight weeks of daily varnish application to the buccal and labial surfaces of all teeth. Clinical parameters (PII and GI) and bacterial samples from selected teeth were collected at predetermined intervals. Four and eight weeks following the baseline, the PII was significantly different among the groups, with the lowest score in the chlorhexidine group. No significant differences among the three groups were noted for the GI. The chlorhexidine and arginine groups showed significant reductions (p < 0.05 and p < 0.01, respectively) in the number of S. mutans. The arginine group showed a nonsignificant increase in the number of S. sanguis. These results suggest that the topical antimicrobial agents may have some relevance to plaque control among patients with mental retardation.
在一项针对34名年龄在18至45岁之间的智障患者的对照性初步研究中，使用了洗必泰和精氨酸缓释清漆的局部应用。这些患者被分配到以下其中一组：洗必泰（C）组、精氨酸（A）组或安慰剂（P）组。在基线时，先进行专业的洁治，随后四周进行专业刷牙，以使菌斑指数（PII）和牙龈指数（GI）达到1.0，之后对所有牙齿的颊面和唇面进行为期八周的每日清漆涂抹。在预定的时间间隔收集临床参数（PII和GI）以及选定牙齿的细菌样本。在基线后的四周和八周时，各组之间的PII存在显著差异，洗必泰组得分最低。三组之间的GI未观察到显著差异。洗必泰组和精氨酸组的变形链球菌数量显著减少（分别为p < 0.05和p < 0.01）。精氨酸组的血链球菌数量有不显著的增加。这些结果表明，局部抗菌剂可能与智障患者的菌斑控制有一定关联。
