Institute for Knowledge Discovery (BCI Lab), Graz University of Technology Graz, Austria ; BioTechMed Graz, Austria.
Institute of Biophysics and Biomedical Engineering, Faculty of Sciences, University of Lisbon Lisboa, Portugal.
Front Integr Neurosci. 2014 Dec 8;8:93. doi: 10.3389/fnint.2014.00093. eCollection 2014.
Recently we hypothesized that the intention to initiate a voluntary movement at free will may be related to the dynamics of hemodynamic variables, which may be supported by the intertwining of networks for the timing of voluntary movements and the control of cardiovascular variables in the insula. In the present study voluntary movements of 3 healthy subjects were analyzed using fMRI scans at 1.83-s intervals along with the time course of slow hemodynamic changes in sensorimotor networks. For the analyses of BOLD time courses the Wavelet transform coherence (WTC) and calculation of phase-locking values were used. Analyzed was the frequency band between 0.07 and 0.13 Hz in the supplementary motor area (SMA) and insula, two widely separated regions co-active in motor behavior. BOLD signals displayed slow fluctuations, concentrated around 0.1 Hz whereby the intrinsic oscillations in the insula preceded those in the SMA by 0.5-1 s. These preliminary results suggest that slow hemodynamic changes in SMA and insula may condition the initiation of a voluntary movement at free will.
最近，我们假设发起自由意愿的自愿运动的意图可能与血液动力学变量的动态有关，而这可能得到岛叶中用于自愿运动定时和心血管变量控制的网络交织的支持。在本研究中，使用 fMRI 扫描以 1.83 秒的间隔对 3 名健康受试者的自愿运动进行了分析，同时还分析了感觉运动网络中缓慢血液动力学变化的时间过程。对于 BOLD 时程的分析，使用了小波变换相干性 (WTC) 和锁相值的计算。分析了补充运动区 (SMA) 和岛叶中的 0.07 至 0.13 Hz 的频带，这两个区域在运动行为中广泛活跃。BOLD 信号显示出缓慢的波动，集中在 0.1 Hz 左右，岛叶中的固有振荡比 SMA 中的固有振荡提前 0.5-1 秒。这些初步结果表明，SMA 和岛叶中的缓慢血液动力学变化可能为自由意愿的自愿运动的发起提供条件。
