一名家族性地中海热患者出现血管炎和长期强直性脊柱炎。

Taylan Ali, Yildiz Yasar, Sari Ismail, Ozkok Guliz

Department of Rheumatology, Izmir Tepecik Training and Research Hospital, Izmir, Iran.

Department of Internal Medicine, Izmir BozyakaTraining and Research Hospital, Izmir, Iran.

J Res Med Sci. 2014 Oct;19(10):1009-11.

Coexistence of familial Mediterranean fever (FMF) and other inflammatory disorders has been frequently reported, but no specific underlying factor has been identified. We report a patient with FMF who is presented with long-standing ankylosing spondylitis (AS) and cutaneous leukocytoklastic vasculitis (LV) of the lower limbs. It is the first report on combination of FMF with AS and LV. The Mediterranean Fever (MEFV) gene mutation of heterozygote (R202Q/R726A) and HLA-B27 are detected in this case, and are believed to form genetic susceptibility to LV.

家族性地中海热（FMF）与其他炎症性疾病并存的情况已有频繁报道，但尚未确定具体的潜在因素。我们报告一例患有FMF的患者，该患者同时患有长期强直性脊柱炎（AS）和下肢皮肤白细胞碎裂性血管炎（LV）。这是关于FMF与AS和LV合并存在的首例报告。该病例检测到杂合子（R202Q/R726A）的地中海热（MEFV）基因突变和HLA - B27，据信它们形成了对LV的遗传易感性。