Leifer D, Moore T, Ukena T, Wilner D, Thor A, Hedley-Whyte E T
Department of Neurology, Massachusetts General Hospital, Boston.
J Neurosurg. 1989 Nov;71(5 Pt 1):772-6. doi: 10.3171/jns.1989.71.5.0772.
A patient with two intracerebral glioblastomas of differing histology with metastases to the liver in the absence of surgery is reported. The gliomatous nature of the lesions was confirmed by staining for glial fibrillary acidic protein. Histological and immunohistochemical evidence suggests that the metastases arose from the more poorly differentiated of the intracerebral tumors. One of the intracerebral tumors had enhanced expression of the ras p21 oncogene as compared to the other tumors and as compared to nonmalignant brain tissue from this patient.
报告了一名患有两种不同组织学类型的脑内胶质母细胞瘤且已转移至肝脏但未接受手术的患者。通过胶质纤维酸性蛋白染色证实了病变的胶质瘤性质。组织学和免疫组化证据表明，转移灶源自脑内分化较差的肿瘤。与该患者的其他肿瘤以及非恶性脑组织相比，其中一个脑内肿瘤的ras p21癌基因表达增强。
