Department of Psychiatry, Washington University School of Medicine , St Louis, MO , USA ; Department of Neurology, Washington University School of Medicine , St Louis, MO , USA.
Department of Psychiatry, Washington University School of Medicine , St Louis, MO , USA.
PeerJ. 2014 Dec 11;2:e687. doi: 10.7717/peerj.687. eCollection 2014.
A carefully controlled study allowed us to compare the sensitivity of ASL (arterial spin labeling) and BOLD (blood oxygen level dependent) fMRI for detecting the effects of the adenosine A2a antagonist tozadenant in Parkinson disease. The study compared the effect of drug directly or the interaction of the drug with a cognitive task. Only ASL detected the direct effect of tozadenant. BOLD was more sensitive to the cognitive task, which (unlike most drugs) allows on-off comparisons over short periods of time. Neither ASL nor BOLD could detect a cognitive-pharmacological interaction. These results are consistent with the known relative advantages of each fMRI method, and suggest that for drug development, directly imaging pharmacodynamic effects with ASL may have advantages over cognitive-pharmacological interaction BOLD, which has hitherto been the more common approach to pharmacological fMRI.
一项精心控制的研究使我们能够比较 ASL（动脉自旋标记）和 BOLD（血氧水平依赖）fMRI 检测腺苷 A2a 拮抗剂托扎丹特在帕金森病中作用的敏感性。该研究比较了药物直接作用或药物与认知任务相互作用的效果。只有 ASL 检测到托扎丹特的直接作用。BOLD 对认知任务更敏感，这（与大多数药物不同）允许在短时间内进行开/关比较。ASL 和 BOLD 均无法检测到认知药理学相互作用。这些结果与每种 fMRI 方法的已知相对优势一致，并表明对于药物开发，使用 ASL 直接成像药效学效应可能优于迄今为止更常见的药理学 fMRI 认知药理学相互作用方法。
