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动脉自旋标记灌注成像中的附加全脑血流归一化。

Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging.

机构信息

Department of Neurology, Washington University School of Medicine , St Louis, MO , USA ; Department of Psychiatry, Washington University School of Medicine , St Louis, MO , USA.

Department of Psychiatry, Washington University School of Medicine , St Louis, MO , USA.

出版信息

PeerJ. 2015 Mar 17;3:e834. doi: 10.7717/peerj.834. eCollection 2015.

DOI:10.7717/peerj.834
PMID:25802806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4369335/
Abstract

To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.

摘要

为了确定不同的全局脑血流 (gCBF) 归一化方法如何影响图像质量和皮质激活的灵敏度，通过模态 gCBF 的加性或乘性归一化来归一化在视觉任务期间获得的脉冲动脉自旋标记 (pASL) 扫描。通过任一种方法归一化都会增加视觉刺激引起的皮质激活的统计学显著性。然而，通过加性归一化，无论是通过强度直方图还是通过减少灰质和白质内的变异性来判断，图像质量都更好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/36095333068b/peerj-03-834-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/e6b075213276/peerj-03-834-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/0f33bd2a8a7d/peerj-03-834-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/99a585f39995/peerj-03-834-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/36095333068b/peerj-03-834-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/e6b075213276/peerj-03-834-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/0f33bd2a8a7d/peerj-03-834-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/99a585f39995/peerj-03-834-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4369335/36095333068b/peerj-03-834-g004.jpg

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