Fujiwara Y
Nihon Jibiinkoka Gakkai Kaiho. 1989 Jul;92(7):1026-35. doi: 10.3950/jibiinkoka.92.1026.
In the experimental animals, the author succeeded in establishing the pathogenicity of herpes simplex virus (HSV) in the facial nerve. KOS strain of HSV type 1 was inoculated to the tongue or the auricle of the balb/c mouse previously treated by intraperitoneal injection of cyclophosphamide. Between 4 and 12 days after the inoculation, the facial nerves were resected and submitted to histopathological and immunohistochemical investigations. Inflammatory changes were mainly observed in the geniculate ganglion and its proximal portion of the facial nerve irrespective of the site of the inoculation. In the same sites, HSV antigens were proved. The viral geniculate ganglionitis was induced in 21.4% of the animals inoculated to the tongue, 30.0% of those to the unilateral auricle, and 37.5% of those to the bilateral auricles respectively. This experiment demonstrated that HSV inoculated in the site innervated by sensory component of the facial nerve could affect the geniculate ganglion and its neighboring portion. These results presented a substantial support of the viral hypothesis in the etiology of Bell's palsy.
在实验动物中，作者成功地证实了单纯疱疹病毒（HSV）对面神经具有致病性。将1型HSV的KOS株接种到预先经腹腔注射环磷酰胺处理的balb/c小鼠的舌部或耳廓。接种后4至12天，切除面神经并进行组织病理学和免疫组织化学检查。无论接种部位如何，炎症变化主要见于膝状神经节及其面神经近端部分。在相同部位，证实存在HSV抗原。分别在接种到舌部的动物中21.4%、接种到单侧耳廓的动物中30.0%以及接种到双侧耳廓的动物中37.5%诱发了病毒性膝状神经节炎。该实验表明，接种于面神经感觉成分支配部位的HSV可影响膝状神经节及其邻近部分。这些结果为贝尔麻痹病因学中的病毒假说提供了有力支持。
