Garg Tarun, Rath Goutam, Goyal Amit K
Department of Pharmaceutics, ISF College of Pharmacy , Moga, Punjab , India.
J Drug Target. 2015 Apr;23(3):202-21. doi: 10.3109/1061186X.2014.992899. Epub 2014 Dec 24.
Nanofiber scaffold formulations (diameter less than 1000 nm) were successfully used to deliver the drug/cell/gene into the body organs through different routes for an effective treatment of various diseases. Various fabrication methods like drawing, template synthesis, fiber-mesh, phase separation, fiber-bonding, self-assembly, melt-blown, and electrospinning are successfully used for fabrication of nanofibers. These formulations are widely used in various fields such as tissue engineering, drug delivery, cosmetics, as filter media, protective clothing, wound dressing, homeostatic, sensor devices, etc. The present review gives a detailed account on the need of the nanofiber scaffold formulation development along with the biomaterials and techniques implemented for fabrication of the same against innumerable diseases. At present, there is a huge extent of research being performed worldwide on all aspects of biomolecules delivery. The unique characteristics of nanofibers such as higher loading efficiency, superior mechanical performance (stiffness and tensile strength), controlled release behavior, and excellent stability helps in the delivery of plasmid DNA, large protein drugs, genetic materials, and autologous stem-cell to the target site in the future.
纳米纤维支架制剂（直径小于1000纳米）已成功用于通过不同途径将药物/细胞/基因输送到身体器官，以有效治疗各种疾病。诸如拉伸、模板合成、纤维网、相分离、纤维粘结、自组装、熔喷和静电纺丝等各种制造方法已成功用于制造纳米纤维。这些制剂广泛应用于组织工程、药物递送、化妆品、过滤介质、防护服、伤口敷料、稳态、传感装置等各个领域。本综述详细阐述了纳米纤维支架制剂开发的必要性，以及用于制造该制剂以对抗无数疾病的生物材料和技术。目前，全球正在对生物分子递送的各个方面进行大量研究。纳米纤维的独特特性，如更高的负载效率、卓越的机械性能（硬度和拉伸强度）、控释行为和出色的稳定性，有助于在未来将质粒DNA、大型蛋白质药物、遗传物质和自体干细胞输送到靶位点。
