ISF College of Pharmacy, Department of Pharmaceutics , Moga, Punjab , India +91 814 626 5364 ;
Expert Opin Drug Deliv. 2014 May;11(5):767-89. doi: 10.1517/17425247.2014.891014. Epub 2014 Mar 26.
Biomaterial-based scaffold formulations (three-dimensional Porous matrix, nano-fibre mesh, hydrogels and microspheres) are the major components that are used to deliver the bioactive molecules into the body organs through different routes for an effective treatment of various diseases.
Various fabrication techniques such as freeze-drying, polymerisation, spray drying, gas foaming, supercritical fluid technology, etc., are successfully used for fabrication of scaffold formulations. Due to their unique characteristics, these formulations are widely used against various diseases such as tuberculosis, bone defects, cartilage repair, skin diseases, cardiovascular diseases, periodontal diseases, wound dressing, etc.
The study of biomaterial-based scaffold formulations is exhilarating with novel approaches to drug/cell/gene delivery being developed all the time. At present, there is a huge extent of research being performed worldwide on all aspects of tissue engineering/drug or gene delivery. In the future, the main focus will be on the development of more patient compliant, sustained and controlled delivery systems against various diseases by modification of polymers, manufacturing technologies as well as carrier systems.
生物材料基支架配方（三维多孔基质、纳米纤维网、水凝胶和微球）是主要成分，通过不同途径将生物活性分子递送到体内器官，以有效治疗各种疾病。
各种制造技术，如冷冻干燥、聚合、喷雾干燥、气体发泡、超临界流体技术等，成功地用于制造支架配方。由于其独特的特性，这些配方被广泛应用于各种疾病，如结核病、骨缺损、软骨修复、皮肤病、心血管疾病、牙周病、伤口敷料等。
生物材料基支架配方的研究令人兴奋，因为一直在开发新的药物/细胞/基因传递方法。目前，全世界都在进行大量的组织工程/药物或基因传递的各个方面的研究。未来的主要重点将是通过聚合物、制造技术以及载体系统的改性，开发更多符合患者需求、持续和控制释放的针对各种疾病的系统。
