Imamura Y, Murahashi N, Suenaga A, Otagiri M
Yakugaku Zasshi. 1989 Jun;109(6):432-6. doi: 10.1248/yakushi1947.109.6_432.
The orally co-administered sodium bicarbonate significantly enhanced the blood concentration of sulfadimethoxine at the early stage after oral administration to rabbits, by increasing its intestinal absorption. On the other hand, the sodium bicarbonate significantly reduced the blood concentration of sulfisoxazole at the elimination phase after oral administration to rabbits, by increasing its urinary excretion. The fact that sodium bicarbonate exhibits different effects in the disposition of these two sulfonamides is an interesting example to gain a better understanding for the complexity of drug interaction.
口服给予碳酸氢钠后，通过增加肠道吸收，显著提高了家兔口服磺胺二甲氧嘧啶后早期的血药浓度。另一方面，碳酸氢钠通过增加家兔口服磺胺异恶唑后的尿排泄，在消除阶段显著降低了其血药浓度。碳酸氢钠在这两种磺胺类药物处置过程中表现出不同作用，这是一个有助于更好理解药物相互作用复杂性的有趣例子。
