Winklewski Pawel J, Radkowski Marek, Demkow Urszula
Institute of Human Physiology, Medical University of Gdansk, Tuwima Street 15, 80-210, Gdansk, Poland.
Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, Warsaw, Poland.
J Neuroinflammation. 2014 Dec 24;11:213. doi: 10.1186/s12974-014-0213-4.
The immune system response and inflammation play a key role in brain injury during and after a stroke. The acute immune response is responsible for secondary brain tissue damage immediately after the stroke, followed by immunosuppression due to sympathetic nervous system activation. The latter increases risk of infection complications, such as pneumonia. The pneumonia-related inflammatory state can release a bystander autoimmune response against central nervous system antigens, thereby initiating a vicious circle. The aim of this review is to summarize the relationship between ischemic stroke, sympathetic nervous system activation and pulmonary infection.
免疫系统反应和炎症在中风期间及之后的脑损伤中起关键作用。急性免疫反应是中风后立即导致继发性脑组织损伤的原因，随后由于交感神经系统激活而出现免疫抑制。后者增加了感染并发症的风险，如肺炎。与肺炎相关的炎症状态可引发针对中枢神经系统抗原的旁观者自身免疫反应，从而形成恶性循环。本综述的目的是总结缺血性中风、交感神经系统激活与肺部感染之间的关系。
