State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Front Immunol. 2019 Nov 26;10:2781. doi: 10.3389/fimmu.2019.02781. eCollection 2019.
The immune system is rapidly activated after ischemic stroke. As immune cells migrate and infiltrate across the blood-brain barrier into the ischemic region, a cascade of cellular and molecular biological reactions occur, involving migrated immune cells, resident glial cells, and the vascular endothelium. These events regulate infarction evolution and thus influence the outcome of ischemic stroke. Most immune cells exert dual effects on cerebral ischemia, and some crucial cells may become central targets in ischemic stroke treatment and rehabilitation.
免疫系统在缺血性中风后迅速激活。随着免疫细胞迁移并穿过血脑屏障渗透到缺血区域，一系列细胞和分子生物学反应发生，涉及迁移的免疫细胞、固有神经胶质细胞和血管内皮细胞。这些事件调节梗死的演变，从而影响缺血性中风的结局。大多数免疫细胞对脑缺血有双重作用，一些关键细胞可能成为缺血性中风治疗和康复的中枢靶点。
