Magnani Corrado, Mattioli Stefano, Miligi Lucia, Ranucci Alessandra, Rondelli Roberto, Salvan Alberto, Bisanti Luigi, Masera Giuseppe, Rizzari Carmelo, Zambon Paola, Cannizzaro Santina, Gafà Lorenzo, Luzzatto Lia Lidia, Benvenuti Alessandra, Michelozzi Paola, Kirchmayer Ursula, Cocco Pierluigi, Biddau Pierfranco, Galassi Claudia, Celentano Egidio, Guarino Erni, Assennato Giorgio, de Nichilo Gigliola, Merlo Domenico Franco, Bocchini Vittorio, Pannelli Franco, Mosciatti Paola, Minelli Liliana, Chiavarini Manuela, Cuttini Marina, Casotto Veronica, Torregrossa Maria Valeria, Valenti Rosalia Maria, Forastiere Francesco, Haupt Riccardo, Lagorio Susanna, Risica Serena, Polichetti Alessandro
Ital J Pediatr. 2014 Dec 24;40:103. doi: 10.1186/s13052-014-0103-5.
Aetiology of childhood leukaemia and childhood neoplasm is poorly understood. Information on the prevalence of risk factors in the childhood population is limited. SETIL is a population based case-control study on childhood leukaemia, conducted with two companion studies on non-Hodgkin Lymphoma (NHL) and neuroblastoma. The study relies on questionnaire interviews and 50 Hz magnetic field (ELF-MF) indoor measurements. This paper discusses the SETIL study design and includes descriptive information.
The study was carried out in 14 Italian regions (78.3% of Italian population aged 0-10). It included leukaemia, NHL and neuroblastoma cases incident in 0-10 year olds in 1998-2001, registered by the Italian Association of Paediatric Haematology and Oncology (AIEOP) (accrual over 95% of estimated incidence). Two controls for each leukaemia case were randomly sampled from the Local Health Authorities rolls, matched by gender, birthdate and residence. The same controls were used in NHL and neuroblastoma studies. Parents were interviewed at home on: physical agents (ELF-MF and ionizing radiation), chemicals (smoking, solvents, traffic, insecticides), occupation, medical and personal history of children and parents, infectious diseases, immunizations and associated factors. Occupational exposure was collected using job specific modules. ELF-MF was measured in the main rooms (spot measurement) and close to child's bed (48 hours measurement).
The study included: 683 leukaemia cases (87% ALL, 13% AnLL), 97 NHL, 155 neuroblastomas, and 1044 controls.
SETIL represents a data source on exposure of Italian children to a broad array of potential carcinogenic factors.
儿童白血病和儿童肿瘤的病因尚不清楚。关于儿童人群中危险因素患病率的信息有限。SETIL是一项基于人群的儿童白血病病例对照研究，并与两项关于非霍奇金淋巴瘤（NHL）和神经母细胞瘤的配套研究同时进行。该研究依靠问卷调查和50赫兹极低频磁场（ELF-MF）室内测量。本文讨论了SETIL研究设计并包括描述性信息。
该研究在意大利14个地区开展（占意大利0至10岁人口的78.3%）。研究纳入了1998年至2001年期间0至10岁新发病的白血病、NHL和神经母细胞瘤病例，这些病例由意大利儿科血液学和肿瘤学协会（AIEOP）登记（累计发病率超过估计发病率的95%）。每个白血病病例的两名对照从当地卫生当局的名册中随机抽取，按性别、出生日期和居住地进行匹配。相同的对照用于NHL和神经母细胞瘤研究。在家中对父母进行访谈，内容包括：物理因素（ELF-MF和电离辐射）、化学物质（吸烟、溶剂、交通、杀虫剂）、职业、儿童和父母的医疗及个人病史、传染病、免疫接种及相关因素。使用特定工作模块收集职业暴露信息。在主要房间（定点测量）和儿童床边附近（48小时测量）测量ELF-MF。
该研究包括：683例白血病病例（87%为急性淋巴细胞白血病，13%为急性非淋巴细胞白血病）、97例NHL、155例神经母细胞瘤和1044名对照。
SETIL是意大利儿童接触多种潜在致癌因素的一个数据源。
