Iarovaia O V, Ioudinkova E S, Petrova N V, Dolgushin K V, Kovina A V, Nefedochkina A V, Vassetzky Y S, Razin S V
Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
Biochemistry (Mosc). 2014 Nov;79(11):1141-50. doi: 10.1134/S0006297914110017.
The α- and β-globin gene domains are a traditional model for study of the domain organization of the eucaryotic genome because these genes encode hemoglobin, a physiologically important protein. The α-globin and β-globin gene domains are organized in completely different ways, while the expression of globin genes is tightly coordinated, which makes it extremely interesting to study the origin of these genes and the evolution of their regulatory systems. In this review, the organization of the α- and β-globin gene domains and their genomic environment in different taxonomic groups are comparatively analyzed. A new hypothesis of possible evolutionary pathways for segregated α- and β-globin gene domains of warm-blooded animals is proposed.
α-珠蛋白基因结构域和β-珠蛋白基因结构域是研究真核生物基因组结构域组织的传统模型，因为这些基因编码血红蛋白，一种具有重要生理功能的蛋白质。α-珠蛋白基因结构域和β-珠蛋白基因结构域的组织方式完全不同，而珠蛋白基因的表达却紧密协调，这使得研究这些基因的起源及其调控系统的进化变得极为有趣。在这篇综述中，对不同分类群体中α-珠蛋白基因结构域和β-珠蛋白基因结构域及其基因组环境进行了比较分析。提出了关于温血动物分离的α-珠蛋白基因结构域和β-珠蛋白基因结构域可能进化途径的新假说。
