Chen Chenyi, Chen Chin-Yau, Yang Chih-Yung, Lin Chi-Hung, Cheng Yawei
Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan;
Department of Surgery, National Yang-Ming University Hospital, Yilan, Taiwan;
J Neurophysiol. 2015 Mar 15;113(6):1842-9. doi: 10.1152/jn.00587.2014. Epub 2014 Dec 24.
Testosterone is capable of altering facial threat processing. Voices, similar to faces, convey social information. We hypothesized that administering a single dose of testosterone would change voice perception in humans. In a placebo-controlled, randomly assigned, double-blind crossover design, we administered a single dose of testosterone or placebo to 18 healthy female volunteers and used a passive auditory oddball paradigm. The mismatch negativity (MMN) and P3a in responses to fearfully, happily, and neutrally spoken syllables dada and acoustically matched nonvocal sounds were analyzed, indicating preattentive sensory processing and involuntary attention switches. Results showed that testosterone administration had a trend to shorten the peak latencies of happy MMN and significantly enhanced the amplitudes of happy and fearful P3a, whereas the happy- and fearful-derived nonvocal MMN and P3a remained unaffected. These findings demonstrated acute effect of testosterone on the neural dynamics of voice perception. Administering a single dose of testosterone modulates preattentive sensory processing and involuntary attention switches in response to emotional voices.
睾酮能够改变面部威胁处理。声音与面孔类似，也传达社会信息。我们假设给予单剂量睾酮会改变人类对声音的感知。在一项安慰剂对照、随机分配、双盲交叉设计中，我们给18名健康女性志愿者给予单剂量睾酮或安慰剂，并采用被动听觉Oddball范式。分析了对恐惧、快乐和中性语调说出的音节“哒哒”以及声学匹配的非语音声音做出反应时的失匹配负波（MMN）和P3a，它们分别指示前注意感觉处理和非自愿注意转换。结果显示，给予睾酮有缩短快乐MMN峰值潜伏期的趋势，并显著增强快乐和恐惧P3a的波幅，而源自快乐和恐惧的非语音MMN和P3a则未受影响。这些发现证明了睾酮对声音感知神经动力学的急性作用。给予单剂量睾酮可调节对情感声音的前注意感觉处理和非自愿注意转换。
