对从加拿大艾伯塔省人和牛身上分离出的大肠杆菌O157:H7及非O157菌株进行分子分析。
Molecular profiling of Escherichia coli O157:H7 and non-O157 strains isolated from humans and cattle in Alberta, Canada.
作者信息
Chui Linda, Li Vincent, Fach Patrick, Delannoy Sabine, Malejczyk Katarzyna, Patterson-Fortin Laura, Poon Alan, King Robin, Simmonds Kimberley, Scott Allison N, Lee Mao-Cheng
机构信息
Provincial Laboratory for Public Health, Edmonton, Alberta, Canada University of Alberta, Edmonton, Alberta, Canada
Provincial Laboratory for Public Health, Edmonton, Alberta, Canada.
出版信息
J Clin Microbiol. 2015 Mar;53(3):986-90. doi: 10.1128/JCM.03321-14. Epub 2014 Dec 24.
Abstract
Virulence markers in Shiga toxin-producing Escherichia coli (STEC) and their association with diseases remain largely unknown. This study determines the importance of 44 genetic markers for STEC (O157 and non-O157) from human clinical cases and their correlation to disease outcome. STEC isolated from a cattle surveillance program were also included. The virulence genes tested were present in almost all O157:H7 isolates but highly variable in non-O157 STEC isolates. Patient age was a significant determinant of clinical outcome.
摘要
产志贺毒素大肠杆菌（STEC）中的毒力标志物及其与疾病的关联在很大程度上仍不清楚。本研究确定了来自人类临床病例的44个STEC（O157和非O157）基因标志物的重要性及其与疾病结局的相关性。还纳入了从牛监测项目中分离出的STEC。所检测的毒力基因几乎存在于所有O157:H7分离株中，但在非O157 STEC分离株中高度可变。患者年龄是临床结局的一个重要决定因素。
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